| Effect of magnesium on mRNA expression and production of endothelin-1 in DOCA-salt hypertensive rats. | |
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MedLine Citation:
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PMID: 12827022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate whether or not the decrease in blood pressure induced by dietary magnesium supplementation in DOCA-salt hypertensive rats is associated with modifications in expression and tissular production of endothelin-1. DOCA-salt treatment increased blood pressure, induced renal and cardiac hypertrophy, and increased endothelin-1 expression and production in the kidney, heart, and aorta. Mg supplementation for 8 weeks lowered blood pressure in DOCA-salt hypertensive rats and prevented hypertrophies and the increase of endothelin-1 expression and production in the heart, aorta, and kidney. Treatment with a receptor ETA antagonist, ABT-627, was used to clarify the relationship between the lowering effect of Mg supplementation on blood pressure and endothelin-1 production. When DOCA-salt rats were treated with ABT-627 for 8 weeks, Mg supplementation failed to lower blood pressure. In conclusion, these findings suggest that the lowering effect of Mg supplementation on blood pressure requires an inhibitory effect on endothelin-1 activity and/or endothelin-1 production in DOCA-salt hypertensive rats. |
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Authors:
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Nathalie Berthon; Pascal Laurant; Dominique Fellmann; Alain Berthelot |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 42 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-26 Completed Date: 2003-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 24-31 Citation Subset: IM |
Affiliation:
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Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Université de Franche-Comté, Besançon, France. nathalie1de@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism Blood Pressure / drug effects Desoxycorticosterone Disease Models, Animal Endothelin-1 / biosynthesis*, metabolism Enzyme-Linked Immunosorbent Assay Heart Rate / drug effects Heart Ventricles / metabolism Hypertension / chemically induced, drug therapy*, metabolism Kidney / metabolism Magnesium Oxide / blood, therapeutic use* Male Organ Size / drug effects Pyrrolidines / pharmacology RNA, Messenger / analysis* Rats Rats, Sprague-Dawley Receptors, Endothelin / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/A 127722; 0/Endothelin-1; 0/Pyrrolidines; 0/RNA, Messenger; 0/Receptors, Endothelin; 1309-48-4/Magnesium Oxide; 64-85-7/Desoxycorticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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