| Effect of magnesium deficiency on delta 6 desaturase activity and fatty acid composition of rat liver microsomes. | |
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MedLine Citation:
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PMID: 2555646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental Mg2+ deficiency was induced in a group of rats by feeding them a Mg2+-deficient diet for 23 days. They were pair-fed to compare with a control group of rats fed a Mg2+-sufficient diet. In the Mg2+-deficient group the plasma total cholesterol and triglyceride levels were increased while HDL-cholesterol was decreased. In the Mg2+-deficient group the plasma level of thiobarbituric acid reacting substances (TBARS) used as a measure for lipid peroxidation was increased. The increase was attributed to the increased cytosolic Ca2+ in Mg2+-deficiency which can cause: 1) increase of hydro and endoperoxide levels as a consequence of the increase of arachidonic acid release and eicosanoid synthesis in Mg2+-deficiency, and 2) inhibition of the mitochondrial respiratory activity and activation of Ca2+-dependent proteases which may activate the conversion of xanthine dehydrogenase to xanthine oxidase which generates active O2 species. In the Mg2+-deficient group, the fatty acid composition of the liver microsomes indicated a slower rate of conversion of linoleic acid to arachidonic acid which was consistent with the decrease of delta 6 desaturase activity in liver microsomes of Mg2+-deficient rats as measured in vitro. The decrease of delta 6 desaturase activity was attributed to the lower concentration of actual enzyme molecules as a result of the decreased rate of protein synthesis in Mg2+-deficiency. The possible effects of the increased catecholamine release in Mg2+-deficiency are discussed. |
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Authors:
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M M Mahfouz; F A Kummerow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 24 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-12-29 Completed Date: 1989-12-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 727-32 Citation Subset: IM |
Affiliation:
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Burnsides Research Laboratory, University of Illinois, Urbana 61801. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Arachidonic Acid Arachidonic Acids / metabolism Cholesterol / blood Cholesterol, HDL / blood Coenzyme A / metabolism Cyclic AMP / metabolism Fatty Acid Desaturases / metabolism* Fatty Acids / metabolism* Fatty Acids, Nonesterified / metabolism Hydroxymethylglutaryl CoA Reductases / metabolism Linoleoyl-CoA Desaturase Lipid Peroxides / blood Magnesium / pharmacology Magnesium Deficiency / enzymology* Male Microsomes, Liver / enzymology* Rats Rats, Inbred Strains Thiobarbiturates Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Cholesterol, HDL; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Lipid Peroxides; 0/Thiobarbiturates; 0/Triglycerides; 504-17-6/thiobarbituric acid; 506-32-1/Arachidonic Acid; 56-65-5/Adenosine Triphosphate; 57-88-5/Cholesterol; 60-92-4/Cyclic AMP; 7439-95-4/Magnesium; 85-61-0/Coenzyme A; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.3/Linoleoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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