Document Detail


Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery.
MedLine Citation:
PMID:  10334795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the effect of dietary Mg deficiency (80 mg/kg versus control diet: 960 mg/kg) on blood pressure and mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously with an echo-tracking device. At 19 weeks, systolic, diastolic, and mean blood pressures were higher in Mg-deficient rats. Histological examination showed an increase in cross-sectional area, intima-media thickness, and media-to-lumen ratio in carotid artery of Mg-deficient rats. Mg deficiency did not modify the arterial distensibility-blood pressure curve. At mean blood pressure, arterial distensibility was significantly less in 19-week-old rats than in 5-week-old rats of both control and Mg-deficient groups. A significant interaction between age and Mg-deficient diet on arterial distensibility (P<0.04) indicates an accelerated age-dependent decreased arterial distensibility with Mg deficiency. At 19 weeks, the artery was stiffer in hypertensive Mg-deficient rats, as illustrated by a shift to higher levels of the incremental elastic modulus-stress curve. In conclusion, the increased blood pressure and the vascular morphological alterations observed in Mg-deficient rats may contribute to an accelerated alteration of the wall material, which in turn leads to a stiffening of the carotid artery.
Authors:
P Laurant; D Hayoz; H R Brunner; A Berthelot
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  33     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1105-10     Citation Subset:  IM    
Affiliation:
Laboratoire Physiologie, Pharmacologie, et Nutrition Pr&eacute. pascal.laurant@univ-fcomte.fr
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Biomechanics
Blood Pressure*
Calcium / blood
Carotid Artery, Common / pathology,  physiology*,  ultrasonography
Cholesterol / blood
Elasticity
Hemodynamics
Hypertension / blood,  etiology,  physiopathology
Magnesium / blood
Magnesium Deficiency / complications*
Male
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
57-88-5/Cholesterol; 7439-95-4/Magnesium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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