Document Detail

Effect of macronutrient composition on postprandial peptide YY levels.
MedLine Citation:
PMID:  17726080     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Peptide YY (PYY) is released from the distal small intestine and colon after meals and reduces appetite by increasing satiety. The amount of PYY released is proportional to calories ingested. Fat ingestion has also been reported to stimulate PYY release.
OBJECTIVE: The objective of the study was to determine whether macronutrient composition influences postprandial serum PYY levels by comparing 1 wk of a weight-maintenance low-carbohydrate, high-fat (LCHF) diet with a low-fat, high-carbohydrate (LFHC) diet.
METHODS: In this randomized crossover study, 18 obese subjects (14 females, 4 males, mean body mass index 35.6 +/- 2.9 kg/m(2)) were randomly assigned initially to 1 wk of a weight-maintenance LCHF or LFHC diet, after which a test meal of identical composition was given and serum PYY levels were assessed for 2.5 h postprandially. After a 1-wk washout period, subjects were crossed over and retested.
RESULTS: After 1 wk, mean postprandial area under the curve PYY after the LCHF test meal was 1.5-fold greater than after the LFHC test meal (P < 0.001). The LCHF diet led to 55% higher levels of postprandial serum PYY levels, compared with the LFHC diet (P = 0.005).
CONCLUSIONS: These data show that a LCHF diet stimulates PYY secretion more than a LFHC diet in obese individuals.
Paulina A Essah; James R Levy; Sakita N Sistrun; Susan M Kelly; John E Nestler
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2007-08-28
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  92     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-11-21     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4052-5     Citation Subset:  AIM; IM    
Departments of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0111, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adiponectin / blood
Blood Glucose
Body Weight / physiology
Cross-Over Studies
Diet, Carbohydrate-Restricted
Diet, Fat-Restricted
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Energy Intake / physiology
Homeostasis / physiology
Insulin / blood
Insulin Resistance / physiology
Leptin / blood
Middle Aged
Obesity / diet therapy,  metabolism*
Peptide YY / blood*,  secretion
Postprandial Period / physiology*
Grant Support
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Insulin; 0/Leptin; 106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of Iodide on Human Choriogonadotropin, Sodium-Iodide Symporter Expression, and Iodide Uptake ...
Next Document:  Effects of atorvastatin on bone in postmenopausal women with dyslipidemia: a double-blind, placebo-c...