| Effect of macrolides on the expression of HLA-DR and costimulatory molecules on antigen-presenting cells in nasal polyps. | |
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MedLine Citation:
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PMID: 11372931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the basis of macrolide therapy for improvement of chronic sinusitis, we investigated the effect of macrolides on the expression of HLA-DR and costimulatory molecules such as CD54 and CD80 on macrophages in nasal polyps. Nasal polyps taken from 54 patients who had or had not been treated with macrolides were immunohistochemically studied. The percentages of CD68-positive macrophages expressing HLA-DR or CD54 were not significantly different between patients treated with macrolides and those not treated with macrolides. However, among patients exhibiting no atopic predisposition, the number of CD80-positive macrophages was higher in patients treated with macrolides than in those not treated. In addition, the percentage of CD80-positive macrophages was negatively correlated with the percentage of infiltrating eosinophils in the polyps. These results demonstrate that macrophages act as antigen-presenting cells, expressing both major histocompatibility complex II and costimulators, and that the expression of CD80 may play a key role in the immune responses occurring in a nasal polyp. Macrolides may modulate the mucosal immune responses through CD80 expression. |
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Authors:
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Y Iino; Y Sasaki; C Kojima; T Miyazawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 110 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-24 Completed Date: 2001-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: United States |
Other Details:
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Languages: eng Pagination: 457-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-Bacterial Agents / pharmacology* Antigen-Presenting Cells / immunology* Antigens, CD / analysis, drug effects Antigens, CD80 / analysis, drug effects Antigens, Differentiation, Myelomonocytic / analysis, drug effects Child Chronic Disease Female HLA-DR Antigens / analysis* Humans Immunohistochemistry Intercellular Adhesion Molecule-1 / analysis, drug effects Macrolides Male Middle Aged Nasal Polyps / immunology* Sinusitis / drug therapy, immunology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antigens, CD; 0/Antigens, CD80; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/HLA-DR Antigens; 0/Macrolides; 126547-89-5/Intercellular Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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