Document Detail


Effect of lymphocytapheresis plus cyclophosphamide on the course of a chronic progressive form of multiple sclerosis.
MedLine Citation:
PMID:  4066266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a case of a 16 year old boy with a chronic progressive form of Multiple Sclerosis treated with lymphocytapheresis and a low dose regimen of cyclophosphamide. A progressive improvement in the disability index and slowing of the clinical course were obtained. No side effects were observed. Depletion of lymphocytes and their pharmacological suppression point to their possible role in the induction of an immunoregulation of the disease process.
Authors:
S Ferla; G Meneghetti; S Spartà; M Belloni; G Ongaro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  6     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-03     Completed Date:  1986-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  283-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / radiography
Chronic Disease
Cyclophosphamide / therapeutic use*
Disability Evaluation
Humans
Leukapheresis*
Male
Multiple Sclerosis / drug therapy*,  physiopathology,  radiography
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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