Document Detail

Effect of lymphatic outflow pressure on lymphatic albumin transport in humans.
MedLine Citation:
PMID:  11509519     Owner:  NLM     Status:  MEDLINE    
The effects of posture on the lymphatic outflow pressure and lymphatic return of albumin were examined in 10 volunteers. Lymph flow was stimulated with a bolus infusion of isotonic saline (0.9%, 12.6 ml/kg body wt) under four separate conditions: upright rest (Up), upright rest with lower body positive pressure (LBPP), supine rest (Sup), and supine rest with lower body negative pressure (LBNP). The increase in plasma albumin content (Delta Alb) during the 2 h after bolus saline infusion was greater in Up than in LBPP: 82.9 +/- 18.5 vs. -28.4 mg/kg body wt. Delta Alb was greater in LBNP than in Sup: 92.6 vs. -22.5 +/- 18.9 mg/kg body wt (P < 0.05). The greater Delta Alb in Up and Sup with LBNP were associated with a lower estimated lymphatic outflow pressure on the basis of the difference in central venous pressure (Delta CVP). During LBPP, CVP was increased compared with Up: 3.8 +/- 1.4 vs. -1.2 +/- 1.2 mmHg. During LBNP, CVP was reduced compared with Sup: -3.0 +/- 2.2 vs. 1.7 +/- 1.0 mmHg. The translocation of protein into the vascular space after bolus saline infusion reflects lymph return of protein and is higher in Up than in Sup. Modulation of CVP with LBPP or LBNP in Up and Sup, respectively, reversed the impact of posture on lymphatic outflow pressure. Thus posture-dependent changes in lymphatic protein transport are modulated by changes in CVP through its mechanical impact on lymphatic outflow pressure.
J Wu; G W Mack
Related Documents :
15774049 - Microvascular permeability during experimental human endotoxemia: an open intervention ...
2908049 - Effects of fenoldopam on feline intestinal microcirculation.
9657359 - Receptor mechanisms of bradykinin-mediated activation of prenodal lymphatic smooth muscle.
9431509 - Myogenic responses of isolated lymphatics: modulation by endothelium.
2782739 - Mechanisms of late hemodynamic and airway dynamic responses to endotoxin in awake sheep.
6824169 - Pure oxygen breathing increases sheep lung microvascular permeability.
4033199 - Primary lymphedema of the leg: relationship between subcutaneous tissue pressure, intra...
24678899 - Negative association between plasma aldosterone concentration/plasma renin activity and...
22555629 - Investigation of photoplethysmographic signals and blood oxygen saturation values on he...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  91     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-17     Completed Date:  2001-12-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1223-8     Citation Subset:  IM; S    
The John B. Pierce Laboratory, New Haven, Connecticut 06519, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atrial Natriuretic Factor / blood
Blood Pressure / physiology
Central Venous Pressure / physiology
Heart Rate / physiology
Lower Body Negative Pressure
Lymphatic System / physiology*
Posture / physiology
Serum Albumin / metabolism*
Sodium Chloride / administration & dosage
Grant Support
Reg. No./Substance:
0/Serum Albumin; 7647-14-5/Sodium Chloride; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at nigh...
Next Document:  Increased renal tubular sodium reabsorption during exercise-induced hypervolemia in humans.