Document Detail


Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers.
MedLine Citation:
PMID:  23223784     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Herbal teas are usually complex mixtures of therapeutically active compounds. The present study is focused on the interference of flavonoids on the bioavailability of rosmarinic acid, as these types of compounds are often present together in decoctions of medicinal plants, namely Lamiaceae species. The bioavailability of rosmarinic acid was analysed in the decoction of P. barbatus and in mixtures with apigenin and luteolin. Rosmarinic acid in the herbal tea showed a 43% bioavailability through the Caco-2 cells when luteolin and apigenin were approximately 30 μM each. In the artificial mixtures the bioavailability could be increased to 90% when the concentration of flavonoids was increased to 90 μM. The co-administration of substrates of known intestinal transport systems, Pgp, Oatp and MCT, showed that the extract components not only modulated the activity of these transporters but also their own bioavailability was dependent on them. Our results demonstrate that plant extracts with a high diversity of polyphenol compounds may have higher bioavailability than that predicted by the isolated compounds.
Authors:
Pedro L Falé; Lia Ascensão; Maria L M Serralheiro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-6
Journal Detail:
Title:  Food & function     Volume:  -     ISSN:  2042-650X     ISO Abbreviation:  Food Funct     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101549033     Medline TA:  Food Funct     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centro Química e Bioquímica da Faculdade de Ciências da Universidade de Lisboa, Edifício C8, Campo Grande, 1749-016 Lisboa, Portugal. mlserralheiro@fc.ul.pt.
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