Document Detail

Effect of lung inflation on active and passive liquid clearance from in vivo rabbit lung.
MedLine Citation:
PMID:  7943351     Owner:  NLM     Status:  MEDLINE    
Active sodium transport contributes to liquid clearance from the alveoli. We hypothesized that the magnitude of active transport of alveolar liquid depends on the extent to which the alveolar epithelium is stretched and, consequently, on the degree of alveolar inflation. In a study on 38 adult rabbits, the left lung was filled in vivo with a solution of glucose (10 mmol/l) made isosmotic with plasma, using sodium chloride, and held at a constant airway pressure of 3, 6, or 9 cmH2O for 6 h. Alveolar liquid clearance was measured directly as a flow into a left main bronchial catheter. Control animals were compared with animals in which active epithelial sodium transport was inhibited by adding amiloride and phloridzin (both 1 mmol/l) to the instillate. At low inflation, active sodium transport reversed a secretion of liquid into the alveoli; at high inflation, active sodium transport made little or no contribution to transepithelial flow. Hydraulic conductance of the left lung was 1.57 body wt-1. The experiments suggest that pulmonary inflation renders active liquid clearance ineffective.
N G Vejlstrup; C A Boyd; K L Dorrington
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  267     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-22     Completed Date:  1994-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  L482-7     Citation Subset:  IM    
Laboratory of Physiology, Oxford, United Kingdom.
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MeSH Terms
Amiloride / pharmacology
Biological Transport, Active / drug effects
Glucose / pharmacokinetics*
Lung / metabolism,  physiology*
Lung Volume Measurements
Phlorhizin / pharmacology
Physical Stimulation
Sodium / antagonists & inhibitors,  pharmacokinetics
Reg. No./Substance:
0/Solutions; 2609-46-3/Amiloride; 50-99-7/Glucose; 60-81-1/Phlorhizin; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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