| Effect of lung T lymphocytes on fibroblasts in idiopathic pulmonary fibrosis and extrinsic allergic alveolitis. | |
| | |
MedLine Citation:
|
PMID: 2392789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Increased fibroblast replication and interstitial collagen accumulation occur commonly in the interstitial lung disease that progress to fibrosis. The processes controlling lung fibrogenesis are not completely understood, however. This study was designed to analyse the influence of T lymphocytes from lung tissue obtained at open lung biopsy from four patients with idiopathic pulmonary fibrosis and four patients with extrinsic allergic alveolitis on fibroblast proliferation and collagen synthesis in vitro. Lung T cell supernatants from patients with both diseases induced a moderate but significant inhibition of human lung fibroblast cell line growth. In contrast, there was a clear difference in the effect of T cells from the two groups of patients in relation to collagen production. Lung T lymphocytes from all four patients with idiopathic pulmonary fibrosis produced a substantial increase in collagen synthesis (from 371% to 514% of control values), whereas T cells from three of the four patients with extrinsic allergic alveolitis induced a significant decrease in collagen production (to 35%, 36%, and 43% of control values); in the fourth case there was an increase in collagen synthesis but this was lower than that seen with T cells from any of the patients with idiopathic pulmonary fibrosis. Peripheral T cells from six patients and control subjects caused a small increase in fibroblast proliferation and no change in collagen synthesis. The findings suggest that at least two types of interaction occur between lung T cells and fibroblasts in these disorders. A variable degree of inhibition of cell proliferation is observed in response to lung T cell supernatants from patients with both idiopathic pulmonary fibrosis and extrinsic allergic alveolitis; a substantial increase in collagen synthesis is triggered by lymphokines from patients with idiopathic pulmonary fibrosis. |
| | |
Authors:
|
M Selman; G Gonzalez; M Bravo; J Sullivan-Lopez; C Ramos; M Montano; N Barquin; F Vadillo |
Related Documents
:
|
7564789 - Role of thrombin in pulmonary fibrosis. 629479 - Long-term follow-up and bronchial reactivity testing in survivors of the adult respirat... 19395579 - Heart rate recovery after 6-min walk test predicts survival in patients with idiopathic... 2689069 - Pulmonary manifestations of endocrine and metabolic disorders. 11530959 - Prevalence of daytime hypercapnia or hypoxia in patients with osas and normal lung func... 21958049 - Spontaneous remission of idiopathic aldosteronism after long-term treatment with spiron... 20058029 - Longitudinal changes of the swallowing process in subacute stroke patients with aspirat... 12106929 - Early dysfunction and long-term improvement in endothelium-dependent vasodilation in th... 22538329 - Spotty calcification as a marker of accelerated progression of coronary atherosclerosis... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Thorax Volume: 45 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 1990 Jun |
Date Detail:
|
Created Date: 1990-10-04 Completed Date: 1990-10-04 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0417353 Medline TA: Thorax Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 451-5 Citation Subset: IM |
Affiliation:
|
Instituto Nacional de Enfermedades Respiratorias, Mexico, DF, Mexico. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alveolitis, Extrinsic Allergic / pathology* Cell Division Cell Line Cells, Cultured Collagen / biosynthesis Female Fibroblasts / physiology* Humans Lung / pathology* Male Middle Aged Pulmonary Fibrosis / pathology* T-Lymphocytes / physiology* |
| Chemical | |
Reg. No./Substance:
|
9007-34-5/Collagen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical correlates of angiographically diagnosed idiopathic pulmonary hypertension.
Next Document: Changes in pulmonary microvascular permeability accompanying re-expansion oedema: evidence from dual...