Document Detail

Effect of luminal pH on the output of bicarbonate and PGE2 by the normal human stomach.
MedLine Citation:
PMID:  3479379     Owner:  NLM     Status:  MEDLINE    
The gastric output of bicarbonate and prostaglandin E2 has been calculated using a perfusion technique before and after instillation of 100 mM hydrochloric acid into the stomach of seven healthy volunteers. A significant increase in bicarbonate output occurred from 258 +/- 38 mumol/30 min during the basal period to 531 +/- 86 mumol/30 min after return of the intragastric pH to neutral (p less than 0.05). Prostaglandin E2 output also increased significantly from 410 +/- 136 pmol/30 min to 1002 +/- 194 pmol/30 min (p less than 0.05). The changes were caused mainly by an increase in gastric secretory volume with only non-significant increases in concentrations of bicarbonate and prostaglandin E2. The results suggest that mechanisms exist to adjust the rate of gastric bicarbonate secretion to the prevailing intraluminal pH and that this may occur through the release of prostaglandin E2.
J R Crampton; L C Gibbons; W D Rees
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  28     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-01-14     Completed Date:  1988-01-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1291-5     Citation Subset:  AIM; IM    
Department of Gastroenterology, Hope Hospital, University of Manchester School of Medicine, Salford.
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MeSH Terms
Bicarbonates / secretion*
Gastric Mucosa / drug effects,  secretion*
Hydrochloric Acid / pharmacology
Hydrogen-Ion Concentration
Middle Aged
Prostaglandins E / secretion*
Stomach / drug effects
Reg. No./Substance:
0/Bicarbonates; 0/Prostaglandins E; 363-24-6/Dinoprostone; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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