| Effect of low protein diet and surplus of essential amino acids on the serum concentration and the urinary excretion of methylguanidine and guanidinosuccinic acid in chronic renal failure. | |
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MedLine Citation:
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PMID: 492426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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20 patients with moderate renal failure (serum creatinine 4.5--12.0 mg/dl) and some uremic symptoms on a diet ad libitum were treated with a high caloric diet containing 0.5--0.7 g/kg/day protein, supplemented with eight essential amino acids and histidine in the form of solution and/or granules. During the treatment uremic symptoms subsided or diminished without the signs of malnutrition, SUN and the ratio SUN/S-creatinine fell and the nitrogen balance and the ratio N-balance/intake N improved. The serum concentration and the urinary excretion of MG and GSA of the 12 patients were determined by Stein's method using the modified Sakaguchi reaction. In all patients, the serum concentration and the urinary excretion of MG and GSA diminished remarkably during the treatment with a low protein diet alone and furthermore with a low protein diet and essential amino acid supply. We concluded that conservative treatment -- low nitrogen diet supplemented with sufficient calories and essential amino acids -- improved the nutritional state of uremic subjects, and decreased the metabolic production of MG and GSA. The results show that the supplementation of essential amino acids to uremic patients may be a useful treatment. |
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Authors:
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A Ando; Y Orita; K Nakata; Y Tsubakihara; Y Takamitsu; N Ueda; M Yanase; H Abe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephron Volume: 24 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1979 |
Date Detail:
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Created Date: 1979-12-29 Completed Date: 1979-12-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 161-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amino Acids / blood Amino Acids, Essential / pharmacology* Blood Urea Nitrogen Creatinine / metabolism Dietary Proteins / administration & dosage* Female Guanidines / metabolism* Histidine / pharmacology Humans Kidney Failure, Chronic / metabolism* Male Methylguanidine / metabolism* Middle Aged Nitrogen / metabolism Serum Albumin / metabolism Succinates / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Essential; 0/Dietary Proteins; 0/Guanidines; 0/Serum Albumin; 0/Succinates; 471-29-4/Methylguanidine; 60-27-5/Creatinine; 71-00-1/Histidine; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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