Document Detail

Effect of low oral doses of disopyramide and amiodarone on ventricular and atrial arrhythmias of chagasic patients with advanced myocardial damage.
MedLine Citation:
PMID:  3908329     Owner:  NLM     Status:  MEDLINE    
Low-dose (7 mg/kg per day) disopyramide administration to arrhythmic chagasic patients decreased the frequency of ventricular extrasystoles in 4 of 17 patients (24%) and suppressed most complex ventricular arrhythmias in 12 of 15 patients (80%). This assessment was made from 72-h continuous Holter monitoring recorded during the course of this double blind, placebo-controlled randomized crossover study. Seven patients (41%) complained of anticholinergic side effects, but no contractile or conduction system depression was seen. Amiodarone (200 mg) given on a single blind, placebo-controlled basis to 9 of these patients reduced the frequency of ventricular extrasystoles in 6 of 9 patients (67%) and suppressed complex ventricular ectopy in 6 of 7 patients (85%). One patient was unable to tolerate this drug (11%). Both drugs seemed less effective in controlling supraventricular arrhythmias, although disopyramide eliminated paroxysms of supraventricular tachycardia in 9 of 13 (69%) and amiodarone in all 6 patients with this arrhythmia. Amiodarone appears to be a better antiarrhythmic drug for chagasic patients, due to its greater effectiveness and lower incidence of side effects.
H A Carrasco; A V Vicuña; C Molina; A Landaeta; J Reynosa; N Vicuña; A Fuenmayor; F López
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of cardiology     Volume:  9     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-07     Completed Date:  1986-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  425-38     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Amiodarone / administration & dosage,  therapeutic use*
Arrhythmias, Cardiac / drug therapy*,  etiology
Benzofurans / therapeutic use*
Chagas Cardiomyopathy / complications*
Clinical Trials as Topic
Disopyramide / administration & dosage,  therapeutic use*
Double-Blind Method
Heart Atria / physiopathology
Heart Ventricles / physiopathology
Middle Aged
Myocardium / pathology*
Random Allocation
Reg. No./Substance:
0/Benzofurans; 1951-25-3/Amiodarone; 3737-09-5/Disopyramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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