Document Detail

Effect of low-level exposure to ozone on arterial oxygenation in humans.
MedLine Citation:
PMID:  453699     Owner:  NLM     Status:  MEDLINE    
We investigated the effect on arterial blood oxygenation of exposure to 0.2 ppm of ozone in purified air for 2 hours with intermittent light exercise and heat stress. Similar exposures to purified air alone provided control data. In 12 healthy volunteers, blood gases were measured before and during exposure via an indwelling brachial cannula. Six of these subjects and 6 other subjects underwent separate similar studies in which "arterialized" earlobe capillary blood was sampled. Arterial Po2 and alveolar-arterial Po2 differences varied significantly among different experimental conditions, but the variability was similar in the presence or absence of ozone. Small significant variations in body temperature were observed; these did not appear to be sufficient to affect blood gas measurements substantially. Over-all, we found no evidence for an adverse effect of the exposure to ozone on arterial oxygenation.
W S Linn; M P Jones; E A Bachmayer; K W Clark; S K Karuza; J D Hackney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  119     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  731-40     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Gas Analysis
Hot Temperature
Middle Aged
Oxygen Consumption / drug effects*
Ozone / adverse effects*
Physical Exertion
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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