Document Detail

The effect of low-GDP solution on ultrafiltration and solute transport in continuous ambulatory peritoneal dialysis patients.
MedLine Citation:
PMID:  23284074     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several studies have reported benefits for human peritoneal mesothelial cell function of a neutral-pH dialysate low in glucose degradation products (GDPs). However, the effects of low-GDP solution on ultrafiltration (UF), transport of solutes, and control of body water remain elusive. We therefore investigated the effect of low-GDP solution on UF, solute transport, and control of body water.
METHODS: Among 79 new continuous ambulatory peritoneal dialysis (CAPD) patients, 60 completed a 12-month protocol (28 in a lactate-based high-GDP solution group, 32 in a lactate-based low-GDP solution group). Clinical indices--including 24-hour UF volume (UFV), 24-hour urine volume (UV), residual renal function, and dialysis adequacy--were measured at months 1, 6, and 12. At months 1, 6, and 12, UFV, glucose absorption, 4-hour dialysate-to-plasma (D/P) creatinine, and 1-hour D/P Na(+) were assessed during a modified 4.25% peritoneal equilibration test (PET). Body composition by bioelectric impedance analysis was measured at months 1 and 12 in 26 CAPD patients.
RESULTS: Daily UFV was lower in the low-GDP group. Despite similar solute transport and aquaporin function, the low-GDP group also showed lower UFV and higher glucose absorption during the PET. Factors associated with UFV during the PET were lactate-based high-GDP solution and 1-hour D/P Na(+). No differences in volume status and obesity at month 12 were observed, and improvements in hypervolemia were equal in both groups.
CONCLUSIONS: Compared with the high-GDP group, the low-GDP group had a lower UFV during a PET and a lower daily UFV during the first year after peritoneal dialysis initiation. Although the low-GDP group had a lower daily UFV, no difficulties in controlling edema were encountered.
Kyu-Hyang Cho; Jun-Young Do; Jong-Won Park; Kyung-Woo Yoon; Yong-Lim Kim
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2013-01-02
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  33     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:    2013 Jul-Aug
Date Detail:
Created Date:  2013-07-11     Completed Date:  2014-03-13     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  382-90     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Body Composition
Dialysis Solutions / chemistry*
Electric Impedance
Glucose / analysis*
Interleukin-6 / analysis
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Prospective Studies
Reg. No./Substance:
0/Dialysis Solutions; 0/Interleukin-6; IY9XDZ35W2/Glucose
Erratum In:
Perit Dial Int. 2013 Sep-Oct;33(5):473-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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