| Effect of low-fat diet on plasma levels of NF-{kappa}B-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. | |
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MedLine Citation:
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PMID: 21764858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and inflammation are central to tumor growth and progression, but the effect of diet on these processes remains uncertain. We explored changes in 50 plasma cytokines and angiogenic factors (CAFs) in 145 men with prostate cancer enrolled in a pre-operative, randomized controlled phase-II trial with four arms: control (usual diet); low-fat (LF) diet; flaxseed-supplemented (FS) diet; and flaxseed-supplemented, low-fat diet. The mean duration of dietary intervention was 30-31 days. Compared to the control arm, 6 CAFs-including pro-angiogenic factors (stromal-cell derived-1 α and myeloid factors (granulocyte-colony-stimulating factor , macrophage colony-stimulating factor- all decreased in the LF arm compared to controls; 3 and 4 CAFs changed in the FS and FS+LF arms, respectively. Weight loss occurred in the LF arms and significantly correlated with VEGF decreases (P <0.001). The CAFs that changed in the LF arm are all known to be regulated by nuclear factor-kappa B (NF-κB), and a pathway analysis identified NF-κB as the most likely regulatory network associated with these changes in the LF arm, but not in the FS-containing arms. Additionally, a non-significant trend towards reduced NF-κB, VEGF, carbonic anhydrase-IX, and cyclooxygenase-2 immunoreactivity was observed in resected prostate cancer specimens from the LF arm compared to controls. These results suggest that a low-fat diet without flaxseed may reduce levels of specific inflammatory cytokines and angiogenic factors and suggests that the NF-κB pathway may be a mediator of these changes. |
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Authors:
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John V Heymach; Terry J Shackleford; Hai T Tran; Suk-Young Yoo; Kim-Anh Do; Melanie Wergin; Pierre Saintigny; Robin T Vollmer; Thomas J Polascik; Denise C Snyder; Mack T Ruffin; Shaoyu Yan; Mark W Dewhirst; Ajai B Kunnamakkara; Bharat B Aggarwal; Wendy Demark-Wahnefried |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-15 |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: - ISSN: 1940-6215 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Thoracic/Head and Neck Medical Oncology, MD Anderson. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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