Document Detail


Effect of low-dose granulocyte-macrophage colony-stimulating factor (LD-GM-CSF) on platelet transfusion-dependent thrombocytopenia.
MedLine Citation:
PMID:  7942785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor known to promote the proliferation and differentiation of precursors of granulocytes and monocytes. GM-CSF at standard doses (125-500 micrograms/m2) alleviates neutropenia secondary to cytotoxic chemotherapy, myelodysplastic syndromes, and aplastic anemia, but has minimal effect on anemia or thrombocytopenia. GM-CSF at doses < 30 micrograms/m2 has been reported to improve platelet counts in some patients exhibiting cytopenia related to hematologic disorders such as aplastic anemia and myelodysplastic syndrome. Low-dose GM-CSF (10-20 micrograms/m2) was evaluated in 20 patients with transfusion-dependent thrombocytopenia persisting after myeloablative cytotoxic chemotherapy or with disease-related cytopenia. Seven patients (35%) responded as defined by a reduction in the platelet transfusion requirements by at least 75%. Low-dose GM-CSF did not significantly increase neutrophil counts or decrease red blood cell transfusion requirements. These results indicate that low-dose GM-CSF has a thrombopoietic effect in about one-third of patients with platelet transfusion-dependent thrombocytopenia which has not been observed at higher doses.
Authors:
D H Vesole; S Jagannath; L D Glenn; B Barlogie
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  47     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-11-18     Completed Date:  1994-11-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205.
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MeSH Terms
Descriptor/Qualifier:
Blood Platelets / drug effects,  pathology*
Dose-Response Relationship, Drug
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology*,  therapeutic use
Hematopoiesis / drug effects
Humans
Platelet Count / drug effects
Platelet Transfusion*
Thrombocytopenia / blood*,  drug therapy,  etiology
Grant Support
ID/Acronym/Agency:
CA 55819/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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