| Effect of low-dose dopamine on sigmoid colonic intramucosal pH in patients undergoing elective abdominal aortic aneurysm repair. | |
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MedLine Citation:
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PMID: 7648106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of low-dose dopamine administration on intramucosal pH (pHi) of the sigmoid colon and on postoperative function of various organs in patients undergoing elective abdominal aortic aneurysm repair was examined. Nineteen patients were randomized to two groups; nine received dopamine at a rate of 3 micrograms per kg per min for 24 h from induction of anaesthesia and ten control patients received fluids without dopamine. pHi was measured with a silicone tonometer and daily samples of blood were taken for measurement of liver transaminase activity, arterial oxygen saturation and creatinine concentration. Mean(s.e.m.) pHi fell to a significantly lower minimum value in those receiving dopamine compared with control patients (6.86(0.10) versus 7.11(0.08), P < 0.05). Five of the nine patients given dopamine developed intramucosal acidosis compared with only one of the ten control patients (P = 0.06). After operation the mean(s.e.m.) aspartate transaminase concentration in patients given dopamine rose from 33(2) to 80(17) units/l (P < 0.01); in control patients it rose from 32(3) to 59(16) units/l (P = 0.054). No differences between the groups was observed in the postoperative ratio of arterial oxygen saturation to inspired oxygen fraction or creatinine concentrations. These results indicate that dopamine has no beneficial effect on bowel mucosal oxygenation and function of the various organs in patients undergoing aortic aneurysm repair. |
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Authors:
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C V Soong; M I Halliday; J M Hood; B J Rowlands; A A Barros D'Sa |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 82 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-09-26 Completed Date: 1995-09-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 912-5 Citation Subset: AIM; IM |
Affiliation:
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Vascular Surgery Unit, Royal Victoria Hospital, Belfast, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Aneurysm, Abdominal / surgery* Colon, Sigmoid / blood supply, drug effects* Creatine / blood Dopamine / administration & dosage* Humans Hydrogen-Ion Concentration Intestinal Mucosa / drug effects Ischemia / etiology Oxygen / blood Surgical Procedures, Elective Urination / drug effects |
| Chemical | |
Reg. No./Substance:
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57-00-1/Creatine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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