Document Detail

Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate.
MedLine Citation:
PMID:  8902446     Owner:  NLM     Status:  MEDLINE    
The use of steroids for treating male immunological infertility is controversial. The effect of low dose prednisolone on sperm quality in men with antisperm antibodies and the conception rate, was evaluated in 40 men and their wives. Significant circulating antisperm antibodies were detected by immunofluorescence technique. Prednisolone (5 mg) was administered orally, daily for 3-6 months in men with significant antisperm antibodies. Another group of 37 men with significant antisperm antibodies, formed the control group. Both groups had initial pre- and post therapy semen analysis and hypoosmotic swelling (HOS) test. They were followed up for 12-18 months and the pregnancy outcome documented. There were significant improvement in sperm motility and hypoosmatic swelling test with therapy (P < 0.01, P > 0.05) of 13 and 15%, respectively. The pregnancy rate of 20% was much greater than 5% in the control group (P < 0.01). There were no side effects of prednisolone. Low dose prednisolone is useful in Antisperm antibody associated infertility, by improving the sperm quality and giving rise to pregnancies.
A E Omu; F al-Qattan; B Abdul Hamada
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  69     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-20     Completed Date:  1997-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Faculty of Medicine Kuwait University, Maternity Hospital Kuwait, Kuwait.
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MeSH Terms
Autoantibodies / drug effects,  immunology
Cohort Studies
Glucocorticoids / pharmacology*,  therapeutic use
Infertility, Male / drug therapy*,  immunology
Prednisolone / pharmacology*,  therapeutic use
Pregnancy Rate
Semen / cytology,  drug effects
Sperm Count / drug effects
Sperm Motility / drug effects,  physiology
Spermatozoa / drug effects*,  immunology
Treatment Outcome
Reg. No./Substance:
0/Autoantibodies; 0/Glucocorticoids; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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