| Effect of low-dose cisapride on gastric emptying and QTc interval in preterm infants. | |
| | |
MedLine Citation:
|
PMID: 11195234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of the study was a prospective survey of the effects of low-dose cisapride on gastric emptying and QTc interval in very low birthweight infants. Twenty low birthweight infants were studied: mean (SD) gestation 30.5 (2.2) wk; birthweight 1320 (150)g. Gastric emptying was assessed ultrasonically in 15 of these infants, in a randomized blind crossover study, following 24-h low-dose oral cisapride administration (0.1 mg/kg given 8 hourly), or placebo. The QTc interval was also determined in all 20 infants following a 7-d course of cisapride or placebo. CONCLUSIONS: Cisapride significantly shortened both gastric emptying time and QTc interval (p < 0.05) compared to placebo. All infants completed the study without any apparent adverse effects. In conclusion, low-dose cisapride administration significantly improves gastric emptying without increasing the QTc interval. |
| | |
Authors:
|
C Costalos; A Gounaris; E Varhalama; F Kokori; N Alexiou; I Katsarakis |
Related Documents
:
|
7710574 - Neonatal neutropenia in low birthweight premature infants. 6683214 - Sibling birthweights and maternal age in sids cases. 1483814 - Reinterpreting the effects of maternal smoking on infant birthweight and perinatal mort... 2265974 - Birth weight and pathogenesis in phenylketonuria. 2388784 - Semipermeable dressing and transepidermal water loss in premature infants. 9277014 - Hypoglycaemia of the newborn: a review. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 89 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2000 Dec |
Date Detail:
|
Created Date: 2001-01-18 Completed Date: 2001-03-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
|
Languages: eng Pagination: 1446-8 Citation Subset: IM |
Affiliation:
|
Department of Neonatal Medicine, Regional General Hospital of Piraeus, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Cisapride / pharmacology* Female Gastric Emptying / drug effects* Gastrointestinal Agents / pharmacology* Humans Infant, Newborn Infant, Very Low Birth Weight Male Prospective Studies Stomach / ultrasonography |
| Chemical | |
Reg. No./Substance:
|
0/Gastrointestinal Agents; 81098-60-4/Cisapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dextran reduces surfactant inhibition by meconium.
Next Document: Budesonide delivered by dosimetric jet nebulization to preterm very low birthweight infants at high ...