Document Detail

Effect of low-dose amiodarone and magnesium combination on atrial fibrillation after coronary artery surgery.
MedLine Citation:
PMID:  16948756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To evaluate whether postoperative administration of intravenous low-dose amiodarone and magnesium sulfate (MgSO(4)) combination would reduce the incidence of atrial fibrillation following coronary artery bypass grafting (CABG) in normomagnesemic high-risk patients for postoperative atrial fibrillation (POAF). METHODS: A total of 136 patients undergoing elective CABG and had > or =3 risk factors for POAF were prospectively randomized to one of three groups, to receive a single dose of amiodarone (5 mg/kg) and MgSO(4) (1.5 g) (combination group, n = 44), or an equal dose of amiodarone (amiodarone group, n = 44) or equal volumes of saline (control group, n = 48) at early postoperative period. Continuous electrocardiographic (ECG) monitoring was performed for the first 48 hours and an ECG was recorded every 8 hours later. POAF longer than 30 minutes or for any length requiring treatment, and the drug-related side effects were recorded. RESULTS: The study population showed a homogeneous distribution regarding risk factors for POAF and there was no significant difference in patient characteristics, echocardiographic variables, or operative variables among three groups. POAF developed in 4 patients in combination group, in 16 patients in amiodarone group and in 16 patients in control group, representing a 24% relative risk reduction between the combination group and control group (p = 0.023). No statistically significant difference regarding incidence of POAF was observed between amiodarone and control groups. CONCLUSIONS: Combined prophylactic therapy with amiodarone and MgSO(4) at the early postoperative period without a maintenance phase is an effective, simple, well-tolerated, and possibly cost-effective regimen to prevent POAF in normomagnesemic, high-risk patients.
Kerim Cagli; Ozcan Ozeke; Kumral Ergun; Baran Budak; Ertan Demirtas; Cemal Levent Birincioglu; Mustafa Pac
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  21     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-04     Completed Date:  2007-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-64     Citation Subset:  IM    
Department of Cardiovascular Surgery, Türkiye Yuksek Ihtisas Hospital, Anakara, Turkey.
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MeSH Terms
Amiodarone / administration & dosage*,  adverse effects
Anti-Arrhythmia Agents / administration & dosage*,  adverse effects
Atrial Fibrillation / etiology,  prevention & control*
Coronary Artery Bypass* / adverse effects
Coronary Artery Disease / surgery
Dose-Response Relationship, Drug
Drug Therapy, Combination
Injections, Intravenous
Magnesium Sulfate / administration & dosage*,  adverse effects
Middle Aged
Prospective Studies
Research Design
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 7487-88-9/Magnesium Sulfate

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