| Effect of low-dose amiodarone and magnesium combination on atrial fibrillation after coronary artery surgery. | |
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MedLine Citation:
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PMID: 16948756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To evaluate whether postoperative administration of intravenous low-dose amiodarone and magnesium sulfate (MgSO(4)) combination would reduce the incidence of atrial fibrillation following coronary artery bypass grafting (CABG) in normomagnesemic high-risk patients for postoperative atrial fibrillation (POAF). METHODS: A total of 136 patients undergoing elective CABG and had > or =3 risk factors for POAF were prospectively randomized to one of three groups, to receive a single dose of amiodarone (5 mg/kg) and MgSO(4) (1.5 g) (combination group, n = 44), or an equal dose of amiodarone (amiodarone group, n = 44) or equal volumes of saline (control group, n = 48) at early postoperative period. Continuous electrocardiographic (ECG) monitoring was performed for the first 48 hours and an ECG was recorded every 8 hours later. POAF longer than 30 minutes or for any length requiring treatment, and the drug-related side effects were recorded. RESULTS: The study population showed a homogeneous distribution regarding risk factors for POAF and there was no significant difference in patient characteristics, echocardiographic variables, or operative variables among three groups. POAF developed in 4 patients in combination group, in 16 patients in amiodarone group and in 16 patients in control group, representing a 24% relative risk reduction between the combination group and control group (p = 0.023). No statistically significant difference regarding incidence of POAF was observed between amiodarone and control groups. CONCLUSIONS: Combined prophylactic therapy with amiodarone and MgSO(4) at the early postoperative period without a maintenance phase is an effective, simple, well-tolerated, and possibly cost-effective regimen to prevent POAF in normomagnesemic, high-risk patients. |
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Authors:
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Kerim Cagli; Ozcan Ozeke; Kumral Ergun; Baran Budak; Ertan Demirtas; Cemal Levent Birincioglu; Mustafa Pac |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cardiac surgery Volume: 21 ISSN: 0886-0440 ISO Abbreviation: J Card Surg Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2007-06-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908809 Medline TA: J Card Surg Country: United States |
Other Details:
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Languages: eng Pagination: 458-64 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Türkiye Yuksek Ihtisas Hospital, Anakara, Turkey. kerimcagli@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / administration & dosage*, adverse effects Anti-Arrhythmia Agents / administration & dosage*, adverse effects Atrial Fibrillation / etiology, prevention & control* Coronary Artery Bypass* / adverse effects Coronary Artery Disease / surgery Dose-Response Relationship, Drug Drug Therapy, Combination Electrocardiography Female Humans Incidence Injections, Intravenous Magnesium Sulfate / administration & dosage*, adverse effects Male Middle Aged Prospective Studies Research Design Risk Factors Treatment Outcome Turkey |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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