Document Detail

Effect of low dietary calcium intake on blood pressure and pressure natriuresis response in rats: a possible role of the renin-angiotensin system.
MedLine Citation:
PMID:  8860101     Owner:  NLM     Status:  MEDLINE    
Dietary Ca is an important modulator of blood pressure in humans and rats. Since the kidney plays a key role in the pathogenesis of hypertension, the effects of a low Ca diet (0.01% Ca) on blood pressure and pressure natriuresis response were studied in normotensive Sprague-Dawley rats. In addition, a possible role of the renin-angiotensin system in the development of hypertension and an altered pressure natriuresis response resulting from low dietary Ca intake was examined. In the low Ca diet group, systolic blood pressure measured by the tail-cuff method was significantly higher than in the normal Ca diet group (1,1% Ca) 1 week after the diet (1 13.0 +/- 7.1 vs. 105.0 +/- 9.5mmHg, p < 0.05). After 4 weeks, the hypertension was more pronounced. Low dietary Ca intake significantly inhibited the water and sodium excretory responses to acute elevation of renal perfusion pressure by tightening an infrarenal aortic constriction. Treatment with an inhibitor of angiotensin-converting enzyme, captopril (30 mg/kg/day), completely abolished the elevation of blood pressure and attenuated the reduced pressure natriuresis response observed in Ca-deficient rats. Although plasma renin activity was not different between the low and normal Ca diet groups after the 2-week dietary regimen, the pressor response to angiotensin II was enhanced by 30% in the low Ca diet group and there was a significant difference in the pressor response between the two groups. These results suggest a possible involvement of the renin-angiotensin system in the development of hypertension and an inhibitory effect on the pressure natriuresis response caused by low dietary Ca intake, via an enhanced sensitivity to angiotensin II.
S Yuasa; T Sumikura; T Yura; N Takahashi; T Shoji; K Uchida; H Fujioka; S Miki; H Matsuo; Y Takamitsu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  5     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1997-05-29     Completed Date:  1997-05-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Second Department of Internal Medicine, Kagawa Medical School, Japan.
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MeSH Terms
Analysis of Variance
Angiotensin II / pharmacology
Blood Pressure / physiology*
Calcium / deficiency*
Calcium, Dietary / administration & dosage*
Electrolytes / blood
Hypertension / blood,  physiopathology*
Kidney Function Tests
Natriuresis / physiology*
Rats, Sprague-Dawley
Renin / blood
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Calcium, Dietary; 0/Electrolytes; 11128-99-7/Angiotensin II; 7440-70-2/Calcium; EC

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