Document Detail


Effect of low-density lipoprotein apheresis on lipoprotein-associated phospholipase A2.
MedLine Citation:
PMID:  15878003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a proinflammatory participant in atherosclerosis and a potential biomarker for coronary heart disease. The effects of low-density lipoprotein (LDL) apheresis on Lp-PLA(2) levels were evaluated in 8 patients with cardiovascular disease. Each patient received 5 LDL apheresis treatments over a 3-month period. The mean direct LDL cholesterol level reduction was 60% (252 to 100 mg/dl). LDL apheresis acutely reduced Lp-PLA(2) by 21.4%. Over the course of treatment, Lp-PLA(2) levels were reduced by 29%. Chronic LDL apheresis significantly reduces Lp-PLA(2) independent of LDL cholesterol, which may be a potential mechanism by which LDL apheresis diminishes coronary heart disease risk.
Authors:
Patrick M Moriarty; Cheryl A Gibson
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  95     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-06-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1246-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA. pmoriart@kumc.edu <pmoriart@kumc.edu>
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MeSH Terms
Descriptor/Qualifier:
1-Alkyl-2-acetylglycerophosphocholine Esterase
Aged
Blood Component Removal*
Cardiovascular Diseases / blood,  therapy*
Cholesterol, LDL / blood*
Female
Humans
Hyperlipoproteinemia Type II / blood,  therapy*
Male
Middle Aged
Phospholipases A / blood*
Phospholipases A2
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2; EC 3.1.1.47/1-Alkyl-2-acetylglycerophosphocholine Esterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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