Document Detail

The effect of low-carbohydrate diet on left ventricular diastolic function in obese children.
MedLine Citation:
PMID:  19674355     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was conducted to evaluate left ventricle (LV) functions using conventional and tissue Doppler imaging in childhood obesity and to identify the effects of diet on LV diastolic functions. METHODS: Conventional and tissue Doppler echocardiographic measurements were compared in 34 obese children and 24 age- and gender-matched lean controls. Fasting plasma glucose, insulin and homeostatic model assessment of insulin resistance levels were also obtained. Thirty-one of the obese children were subjected to a low-carbohydrate diet and their follow-up measurements were obtained after 6 months. RESULTS: Left atrial diameter, LV mass and LV mass index were higher in obese children than in lean controls. Lateral mitral myocardial early diastolic (E(m)) and peak E(m)/myocardial late diastolic (A(m)) were lower, and mitral E/E(m) and lateral mitral myocardial isovolumetric relaxation time were higher in obese subjects than in lean controls. Insulin and homeostatic model assessment of insulin resistance levels were higher in obese patients and decreased significantly after diet. After diet therapy, lateral mitral E(m) and peak E(m)/A(m), were increased, mitral E/E(m) and myocardial isovolumetric relaxation time were decreased. CONCLUSIONS: Obesity predisposes children to increased preload reserve, left ventricular subclinical diastolic dysfunction and deterioration in diastolic filling. Weight reduction with a low-carbohydrate diet seems to be associated with significant improvement in LV diastolic function and a decrease in diastolic filling, as well as causing reversal in insulin resistance seen in obese children.
Cenap Zeybek; Ahmet Celebi; Cigdem Aktuglu-Zeybek; Hasan Onal; Yalim Yalcin; Abdullah Erdem; Celal Akdeniz; Elnur Imanov; Suheyla Altay; Ahmet Aydin
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Publication Detail:
Type:  Journal Article     Date:  2009-08-07
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  52     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  IM    
Pediatric Cardiology Clinic, Siyami Ersek Cardiovascular Training and Research Hospital, Istanbul, Turkey.
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MeSH Terms
Diet, Carbohydrate-Restricted*
Obesity / diet therapy*,  physiopathology*
Ventricular Function, Left*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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