| Effect of loss of regional fat assessed by DXA on insulin resistance and dyslipidaemia in obese men. | |
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MedLine Citation:
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PMID: 20961179 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the impact of reduction in total fat mass (FM) and regional FMs on indices of insulin resistance and dyslipidaemia in obese men (BMI > 30 kg/m²) after a 1-year weight loss (WL), and secondly, to examine the potential predictive effect of baseline insulin resistance on reduction in total and regional FMs. MATERIAL AND METHODS: In nine men with WL > 4 kg, body composition by DXA (dual X-ray absorptiometry) and indices of insulin resistance were assessed: fasting insulin, C-Peptide and HOMA-IR. Insulin sensitivity (QUICKI) and serum lipids were also assessed. RESULTS: Mean WL was 10.8%; Δ trunk and Δ leg FM were reduced by 30.1% and 21.3%, respectively, increasing leg/trunk FM ratio by 13.2%. Improvement in HOMA-IR was 63.1%, insulin 59.1%, and in QUICKI 17.4%. Loss of total FM, trunk FM, and increase in leg/trunk FM ratio were correlated with improvement in HOMA-IR (p < 0.001-0.05). Linear regression analysis of ln-transformed improvements in HOMA-IR was non-significantly related with losses of trunk FM and increases in leg/trunk FM ratio (p = 0.06). Multivariate analysis suggested improvements in fasting insulin and C-Peptide could be explained by leg/trunk FM ratio (R² = 0.60, p = 0.013, R² = 0.37, p = 0.012, respectively) and in HOMA-IR by trunk FM (R² = 0.42, p = 0.06). The loss of FM and change in FM distribution had no effect on serum lipids. CONCLUSION: Both loss of trunk FM and increase in leg/trunk FM ratio assessed by DXA contribute to the improvement in insulin resistance. |
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Authors:
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Gunnar Aasen; Hans Fagertun; Johan Halse |
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Publication Detail:
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Type: Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 70 ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: England |
Other Details:
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Languages: eng Pagination: 547-53 Citation Subset: IM |
Affiliation:
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Spesialistsenteret Pilestredet Park, Oslo, Norway. g.aasen@usa.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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