Document Detail

Effect of losartan in treatment of exercise-induced myocardial ischemia.
MedLine Citation:
PMID:  17996511     Owner:  NLM     Status:  MEDLINE    
Because no controlled clinical studies are available about the possible role of angiotensin II receptor blockers in preventing effort myocardial ischemia, we evaluated the effect of angiotensin II receptor blocker/losartan in preventing exercise-induced myocardial ischemia in patients with coronary artery disease. Twenty-four sedentary patients with chronic stable ischemia were prospectively randomized to 28 days (double blind) of losartan 100 mg or losartan placebo in 2 divided doses. In each patient the treatment was crossed over to the alternative regimen (28 days, double blind) after a 1-week placebo period (single blind). At the end of each phase a new exercise stress test was performed. At baseline, systolic blood pressure was significantly decreased after losartan 100 mg compared with losartan placebo. At submaximal exercise, systolic blood pressure and rate-pressure product were lower after losartan 100 mg administration compared with losartan placebo, and these findings remained significant at 1-mm ST depression and at peak exercise. Losartan 100 mg administration versus losartan placebo significantly delayed the time to 1-mm ST-depression onset and decreased ST-segment depression at peak exercise and time to recovery of ST-segment depression. Losartan 100 mg administration compared with losartan placebo was able to significantly increase exercise duration and maximal workload during exercise stress testing. In conclusion, in our study, losartan decreased electrocardiographic parameters of myocardial ischemia in patients with coronary artery disease, suggesting a possible role of this drug in treatment of patients with effort myocardial ischemia.
Giancarlo Longobardi; Graziamaria Corbi; Francesco Cacciatore; Pasquale Abete; Giuseppe Furgi; Dino Franco Vitale; Franco Rengo; Nicola Ferrara
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-08-30
Journal Detail:
Title:  The American journal of cardiology     Volume:  100     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1517-21     Citation Subset:  AIM; IM    
Cardiology Division, Fondazione Salvatore Maugeri, IRCCS, Scientific Institute of Telese Terme, Telese Terme, Italy.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / therapeutic use*
Blood Pressure / physiology
Coronary Artery Disease / physiopathology*
Cross-Over Studies
Double-Blind Method
Exercise Test*
Losartan / therapeutic use*
Middle Aged
Myocardial Infarction / etiology,  physiopathology,  prevention & control*
Prospective Studies
Systole / physiology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 114798-26-4/Losartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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