Document Detail

Effect of losartan on the blood-brain barrier permeability in diabetic hypertensive rats.
MedLine Citation:
PMID:  14561528     Owner:  NLM     Status:  MEDLINE    
Our previous publication has stressed the benefits of losartan, an angiotensin II receptor blocker, on the permeability of blood-brain barrier (BBB) and blood pressure during L-NAME-induced hypertension. This study reports the impacts of anti-hypertensive treatment by losartan on the brain endothelial barrier function and the arterial blood pressure, during acute hypertension episode, in experimentally diabetic hypertensive rats. Systolic blood pressure measurements were taken with tail cuff method before and during administration of L-NAME (0.5 mg/ml). We induced diabetes by using alloxan (50 mg/kg, i.p). Losartan (3 mg/kg, i.v) was given to rats following the L-NAME treatment. Acute hypertensive vascular injury was induced by epinephrine (40 microg/kg). The BBB disruption was quantified according to the extravasation of the Evans blue (EB) dye. L-NAME induced a significant increase in arterial blood pressure on day 14 in normoglycemic and hyperglycemic rats (p < 0.05). Losartan significantly reduced the increased blood pressure in hypertensive and diabetic hypertensive rats (p < 0.01). Epinephrine-induced acute hypertension in diabetic hypertensive rats increased the content of EB dye dramatically in cerebellum and diencephalon (p < 0.01) and slightly in both cerebral cortex (p < 0.05). Losartan treatment reduced the increased BBB permeability to EB dye in the brain regions of diabetic hypertensive rats treated with epinephrine (p < 0.05). This study indicates that, in diabetic hypertensive rats, epinephrine administration leads to an increase in microvascular-EB-albumin efflux to brain, however losartan treatment significantly attenuates this protein's transport to brain tissue.
M Kaya; R Kalayci; M Küçük; N Arican; I Elmas; H Kudat; F Korkut
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  73     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-16     Completed Date:  2003-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  3235-44     Citation Subset:  IM    
Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa 34 390, Istanbul, Turkey.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Blood-Brain Barrier / drug effects*,  physiology
Diabetes Mellitus, Experimental / complications,  physiopathology*
Epinephrine / pharmacology
Evans Blue / metabolism
Hypertension / chemically induced,  complications,  drug therapy*
Losartan / therapeutic use*
NG-Nitroarginine Methyl Ester / pharmacology
Permeability / drug effects
Rats, Wistar
Reg. No./Substance:
0/Antihypertensive Agents; 114798-26-4/Losartan; 314-13-6/Evans Blue; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-43-4/Epinephrine

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