Document Detail


Effect of long-term valproic acid administration on the efficiency of carnitine reabsorption in humans.
MedLine Citation:
PMID:  9920148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate the etiology of valproic acid-induced carnitine deficiency, we tested the hypothesis that long-term valproic acid administration decreases the rate of carnitine reabsorption. Thirteen healthy men participated in a 34-day protocol in which carnitine clearance was measured before and after 28 days of valproic acid administration. During valproic acid administration (days 6 to 33), plasma free and total carnitine concentrations decreased (18% and 12%, respectively, P<.05) by 16 days, but returned to pretreatment concentrations by 28 days. From day 14 to day 30, the rate of free carnitine excretion was 50% lower than at baseline (day 4, P<.05). Free and total carnitine clearance, indexed to the glomerular filtration rate, was lower after valproic acid administration (P<.01). Contrary to our hypothesis, after 28 days of valproic acid administration, the rate of carnitine reabsorption was enhanced independent of the glomerular filtration rate and filtered load. Changes in the plasma concentration, rate of excretion, and clearance were specific for carnitine and were not generalized in magnitude or direction to the other amino acids. We conclude that the kidney adapts to conserve carnitine during valproic acid administration and therefore does not cause valproic acid-induced carnitine depletion in adults.
Authors:
D D Stadler; J F Bale; C A Chenard; C J Rebouche
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  48     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, and General Clinical Research Center, University of Iowa College of Medicine, Iowa City, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Adult
Anticonvulsants / adverse effects*
Carnitine / deficiency,  metabolism*
Humans
Kidney / metabolism
Male
Valproic Acid / adverse effects*
Grant Support
ID/Acronym/Agency:
RR00059/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants; 541-15-1/Carnitine; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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