| Effect of long term feeding and withdrawal of aflatoxin B1 and ochratoxin A on kidney cell transformation in albino rats. | |
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MedLine Citation:
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PMID: 1794862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subacute doses (1/20 LD50) of aflatoxin B1 and ochratoxin A were fed to weanling albino rats individually and in combination for 36 weeks and then rats were maintained on toxin free normal diet for a period of 24 weeks. Livers of rats were fatty, wherever aflatoxin was administered but the enzyme activity did not show significant differences among various groups. However, in a few individuals whose livers were severely affected, higher concentrations of urine creatinine, liver RNA and DNA, and ALT enzyme activity were recorded. Histopathological examination showed various stages of hepatoma and hepatocarcinoma including nodular hyperplasia, hypertrophy, vacuolisation, degeneration, pseudolobulation, cellular infiltration and fibrosis of liver of rats fed with aflatoxin individually and in combination. Few anaplastic cells in the corticomedullary region and nuclear enlargement of proximal tubular epithelium of kidney were found wherever combined toxin and ochratoxin alone were administered. Liver tumor expression was time dependent. |
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Authors:
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E R Rati; T Shantha; H P Ramesh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 29 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-04-06 Completed Date: 1992-04-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: INDIA |
Other Details:
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Languages: eng Pagination: 813-7 Citation Subset: IM |
Affiliation:
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Department of Microbiology & Sanitation, Central Food Technological Research Institute, Mysore, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aflatoxin B1 / administration & dosage, toxicity* Animals Carcinogens / administration & dosage, toxicity* Cell Transformation, Neoplastic / drug effects* Kidney / cytology, drug effects* Male Ochratoxins / administration & dosage, toxicity* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Ochratoxins; 1162-65-8/Aflatoxin B1; 303-47-9/ochratoxin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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