| Effect of long-term feeding of nivalenol on aflatoxin B1-initiated hepatocarcinogenesis in mice. | |
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MedLine Citation:
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PMID: 1906836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nivalenol, a trichothecene, occurs widely in cereals and foods; our current two-year feeding trial has revealed no tumorigenic activity in female mice. To investigate whether dietary nivalenol modulates the development of aflatoxin B1 (AFB1)-initiated hepatocarcinogenesis, one-week old C57Bl/6 x C3H F1 mice were injected intraperitoneally with 6 mg/kg bw AFB1 and six weeks later fed diets containing 0, 6 or 12 ppm nivalenol for one year. Male mice in all three groups developed hepatocellular carcinomas and adenomas, while the incidences in females were 31% in those given AFB1 alone and 20% and 0 in those given AFB1 with 6 and 12 ppm nivalenol, respectively. These findings indicate that dietary nivalenol suppresses AFB1-initiated hepatocarcinogenesis in female mice, presumably by acting on the promotion step. |
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Authors:
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Y Ueno; T Kobayashi; H Yamamura; T Kato; F Tashiro; K Nakamura; K Ohtsubo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: IARC scientific publications Volume: - ISSN: 0300-5038 ISO Abbreviation: IARC Sci. Publ. Publication Date: 1991 |
Date Detail:
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Created Date: 1991-08-29 Completed Date: 1991-08-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8009542 Medline TA: IARC Sci Publ Country: FRANCE |
Other Details:
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Languages: eng Pagination: 420-3 Citation Subset: IM |
Affiliation:
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Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxin B1 Aflatoxins / toxicity* Animals Carcinogens* Diet Female Liver Neoplasms, Experimental / chemically induced*, prevention & control Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mycotoxins / pharmacology* Sex Factors Trichothecenes / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Carcinogens; 0/Mycotoxins; 0/Trichothecenes; 1162-65-8/Aflatoxin B1; 23282-20-4/nivalenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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