Document Detail

Effect of long-term anti-hypertensive beta-receptor-blocking treatment on haemodynamic and metabolic responses to prolonged exercise in man.
MedLine Citation:
PMID:  1071668     Owner:  NLM     Status:  MEDLINE    
1. Central and regional haemodynamics and leg metabolism at rest, during and after a prolonged exercise were studied in seven untreated hypertensive males before and after a long-term treatment (6 weeks) with an unselective beta-receptor-blocking drug (alprenolol). 2. Alprenolol treatment (200-400 mg, twice daily) decreased arterial blood pressure at rest and during exercise; it reduced heart rate in relation to drug plasma concentrations during and after exercise; it left cardiac output unchanged; it reduced leg blood flow at rest, but had no effect on leg blood flow during exercise. 3. Alprenolol treatment also decreased lipolysis and lactate release in relation to drug plasma concentrations during exercise.
M Frisk-Holmberg; A Juhlin-Dannfeldt; L Jorfeldt; H Aström
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science and molecular medicine. Supplement     Volume:  3     ISSN:  0144-4107     ISO Abbreviation:  Clin Sci Mol Med Suppl     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7907311     Medline TA:  Clin Sci Mol Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  489s-491s     Citation Subset:  IM    
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MeSH Terms
Alprenolol / therapeutic use*
Fatty Acids, Nonesterified / blood
Glycerol / blood
Heart Rate / drug effects
Hypertension / drug therapy*,  metabolism,  physiopathology
Lactates / blood
Leg / blood supply
Physical Exertion*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lactates; 13655-52-2/Alprenolol; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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