Document Detail

Effect of long-term administration of 1,25 (OH)2 vitamin D3 on blood pressure and resistance artery contractility in the spontaneously hypertensive rat.
MedLine Citation:
PMID:  8305169     Owner:  NLM     Status:  MEDLINE    
The effect of long-term daily injection of 1,25 (OH)2 vitamin D3 on blood pressure and contractile force generation by subsequently isolated mesenteric resistance arteries was examined using the spontaneously hypertensive rat (SHR) model of genetic hypertension. Beginning at 6 weeks of age, male SHR were given daily intraperitoneal injections of vehicle, or 1,25 (OH)2 vitamin D3 at 20, 30, or 40 ng/100 g body weight. Body weight and systolic blood pressure were determined weekly. After 9 weeks, serum was prepared for electrolyte analysis and mesenteric resistance arteries were isolated for assessment of contractile function using a wire myograph. Blood pressure became elevated in the rats receiving 20 and 40 ng 1,25 (OH)2 vitamin D3 after 5 weeks and remained elevated in the 40 ng group during the sixth week. Between weeks six to nine, blood pressure continued to rise but was not different among the groups. In addition, during the period between 6 and 9 weeks, there was a decline in the rate of weight gain in rats receiving 30 and 40 ng 1,25 (OH)2 vitamin D3. Serum ionized Ca2+ was significantly elevated in the three groups treated with 1,25 (OH)2 vitamin D3 compared with control. The active stress response of resistance arteries to norepinephrine and arginine vasopressin was significantly elevated in rats that received 30 and 40 ng 1,25 (OH)2 vitamin D3, but no differences in apparent sensitivity to these agonists were detected.(ABSTRACT TRUNCATED AT 250 WORDS)
R D Bukoski; J Li; J Bo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  6     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-16     Completed Date:  1994-03-16     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  944-50     Citation Subset:  IM    
Hypertension Laboratory, University of Texas Medical Branch, Galveston Island 77550
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MeSH Terms
Acetylcholine / pharmacology
Arginine Vasopressin / pharmacology
Arteries / physiology*
Blood Pressure / drug effects,  physiology*
Calcitriol / administration & dosage*,  pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Hypertension / genetics,  physiopathology*
Injections, Intraperitoneal
Norepinephrine / pharmacology
Rats, Inbred SHR
Time Factors
Vascular Resistance / drug effects,  physiology*
Vasoconstriction / drug effects,  physiology*
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 32222-06-3/Calcitriol; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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