Document Detail


Effect of a long- and short-acting beta2-agonist on exercise-induced arterial hypoxemia.
MedLine Citation:
PMID:  12673143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: determine the effect of formoterol and salbutamol on the arterial oxygen saturation (SaO(2)) of highly trained nonasthmatic athletes with exercise-induced arterial hypoxemia (EIAH).
METHODS: Ten male athletes (age = 27.1 +/- 0.7, [OV0312]O(2max) = 65.2 +/- 2.5 mL.kg-1.min-1, SaO(2min) = 91.0 +/- 2.1%) with minimal bronchial reactivity to aerosols (i.e., negative methacholine challenge test) completed three identical exercise sessions differing only by the medication administered. Formoterol (F), a long-acting beta-2 agonist, was compared with salbutamol (S) and a placebo (P). F (12 microg), S (400 microg), or P was administered by a Turbuhaler, 10 min before exercise testing in a double-blind, randomized, three-way crossover design. Testing sessions included an incremental cycle ergometer test to exhaustion, while monitoring SaO(2) and ventilation, and a pre- and postexercise pulmonary function test.
RESULTS: There were no significant differences between the groups in SaO(2) nadir with exercise (F = 92.0 +/- 1.0; S = 92.0 +/- 1.0; P = 91.0 +/- 0.7%). During the maximal incremental test, no differences were observed in SaO(2) or minute ventilation between the three experimental conditions. Pulmonary function tests revealed a significant increase in FEV(1) and FEV(1)/FVC after exercise in all conditions. Drug administration increased FEV(1)/FVC postexercise compared with placebo (F = 87.9 +/- 2.3, S = 87.6 +/- 1.7 > P = 85.6 +/- 2.1%; P < 0.05).
CONCLUSION: An acute, inhaled, therapeutic dose of formoterol or salbutamol did not affect SaO(2) nadir or ventilation kinetics in a group of highly trained nonasthmatic athletes with EIAH.
Authors:
Ian B Stewart; Jane M Labreche; Donald C McKenzie
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  35     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-03     Completed Date:  2004-03-16     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  603-7     Citation Subset:  IM; S    
Affiliation:
School of Human Movement Studies, Queensland University of Technology, Brisbane, Qld, Australia. i.stewart@qut.edu.au
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adrenergic beta-Agonists / administration & dosage,  pharmacology*
Adult
Albuterol / administration & dosage,  pharmacology*
Anoxia / physiopathology*
Cross-Over Studies
Double-Blind Method
Ethanolamines / administration & dosage,  pharmacology*
Exercise / physiology*
Exercise Test
Humans
Male
Oxygen / blood
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Ethanolamines; 18559-94-9/Albuterol; 5ZZ84GCW8B/formoterol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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