Document Detail

Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men.
MedLine Citation:
PMID:  12355334     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the study was to investigate whether a long-lasting bout of exercise modifies the lipolytic beta- and antilipolytic-alpha(2)-adrenergic effect and the antilipolytic effect of insulin in obese subjects. DESIGN: Biopsies of abdominal subcutaneous adipose tissue were performed before and immediately after 2 h exercise (at 50% of VO(2max)) on an ergometric bicycle. SUBJECTS: Nine healthy obese male subjects (mean age 38.0+/-3.5 y; mean body mass index (BMI) 35.6+/-3.9 kg/m(2)) were included in the experiment. METHODS: :The lipolytic responsiveness to adrenaline, isoprenaline (beta-adrenergic agonist), UK-14304 (alpha(2)-adrenergic agonist) and insulin was studied in the isolated fat cell obtained by biopsies of subcutaneous adipose tissue from the peri-umbilical region before and after exercise. RESULTS: After exercise, an increase was observed in spontaneous lipolytic rate, and in the lipolytic effect of isoprenaline, but no modification in the lipolytic action of adrenaline. Antilipolytic effects of UK-14304 and insulin were not changed by the single bout of exercise. CONCLUSION: A single bout of long-term exercise increased the responsiveness of adipose tissue to beta-adrenergic stimulation of lipolysis in obese subjects.
I Harant; F Marion-Latard; F Crampes; I de Glisezinski; M Berlan; V Stich; D Rivière
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  26     ISSN:  0307-0565     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-30     Completed Date:  2002-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  1373-8     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale (INSERM, Unité 317), Université Paul Sabatier, Toulouse, France.
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MeSH Terms
Abdomen / pathology
Adipocytes / drug effects*,  metabolism
Adrenergic Agonists / pharmacology*
Epinephrine / pharmacology
Insulin / pharmacology*
Isoproterenol / pharmacology
Obesity / physiopathology*
Quinoxalines / pharmacology
Time Factors
Reg. No./Substance:
0/Adrenergic Agonists; 0/Quinoxalines; 11061-68-0/Insulin; 51-43-4/Epinephrine; 59803-98-4/brimonidine; 7683-59-2/Isoproterenol

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