| Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men. | |
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MedLine Citation:
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PMID: 12355334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the study was to investigate whether a long-lasting bout of exercise modifies the lipolytic beta- and antilipolytic-alpha(2)-adrenergic effect and the antilipolytic effect of insulin in obese subjects. DESIGN: Biopsies of abdominal subcutaneous adipose tissue were performed before and immediately after 2 h exercise (at 50% of VO(2max)) on an ergometric bicycle. SUBJECTS: Nine healthy obese male subjects (mean age 38.0+/-3.5 y; mean body mass index (BMI) 35.6+/-3.9 kg/m(2)) were included in the experiment. METHODS: :The lipolytic responsiveness to adrenaline, isoprenaline (beta-adrenergic agonist), UK-14304 (alpha(2)-adrenergic agonist) and insulin was studied in the isolated fat cell obtained by biopsies of subcutaneous adipose tissue from the peri-umbilical region before and after exercise. RESULTS: After exercise, an increase was observed in spontaneous lipolytic rate, and in the lipolytic effect of isoprenaline, but no modification in the lipolytic action of adrenaline. Antilipolytic effects of UK-14304 and insulin were not changed by the single bout of exercise. CONCLUSION: A single bout of long-term exercise increased the responsiveness of adipose tissue to beta-adrenergic stimulation of lipolysis in obese subjects. |
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Authors:
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I Harant; F Marion-Latard; F Crampes; I de Glisezinski; M Berlan; V Stich; D Rivière |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Volume: 26 ISSN: 0307-0565 ISO Abbreviation: Int. J. Obes. Relat. Metab. Disord. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-30 Completed Date: 2002-12-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9313169 Medline TA: Int J Obes Relat Metab Disord Country: England |
Other Details:
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Languages: eng Pagination: 1373-8 Citation Subset: IM |
Affiliation:
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Institut National de la Santé et de la Recherche Médicale (INSERM, Unité 317), Université Paul Sabatier, Toulouse, France. crampes.f@chu-toulouse.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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pathology Adipocytes / drug effects*, metabolism Adrenergic Agonists / pharmacology* Adult Epinephrine / pharmacology Exercise* Humans Insulin / pharmacology* Isoproterenol / pharmacology Lipolysis Male Obesity / physiopathology* Quinoxalines / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 0/Quinoxalines; 11061-68-0/Insulin; 51-43-4/Epinephrine; 59803-98-4/brimonidine; 7683-59-2/Isoproterenol |
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