Document Detail

Effect of long-chain mono-unsaturated and n-3 polyunsaturated fatty acids on postprandial blood and liver lipids in rats.
MedLine Citation:
PMID:  8571076     Owner:  NLM     Status:  MEDLINE    
The effects on blood and liver lipids after feeding rats with concentrated fractions from fish oil consisting of mono-unsaturated fatty acids (80% C20:1 and 22:1) or n-3 polyunsaturated fatty acids (85% C20:5 and 22:6 n-3) were examined. Mono-unsaturated fat had no effects on plasma triacylglycerol, total cholesterol phospholipids or unesterified fatty acid as compared to controls (lard). However, n-3 polyunsaturated fatty acid-fed animals showed a significant decrease in plasma triacylglycerol (74%), phospholipids (40%) and unesterified fatty acids (52%). The concentrated fractions had no effects on liver lipids. While the n-3 diet increased peroxisomal beta-oxidation 2.5-fold, there was only a slight increase with the mono-unsaturated diet. The fatty acid composition in plasma and liver phospholipids was changed with the various diets; 20:4 n-6 was significantly reduced in plasma and liver with the mono-unsaturated diet, and with the n-3 diet in liver. The mono-unsaturated diet, and especially the n-3 diet, increased the 20:5 n-3 level in both plasma and liver. Our results indicate that long-chain mono-unsaturated fatty acids in fish oil do not change the levels of plasma lipids. The beneficial role of fish oil on the level of blood lipids, may therefore be mostly attributed to the effects of long-chain n-3 fatty acids. However, the low 20:4 n-6 and high 20:5 n-3 levels in plasma and liver phospholipids with the concentrated mono-unsaturated fatty acid diet may be of importance for a favourable haemostatic balance with regard to cardiovascular diseases.
B Halvorsen; A C Rustan; E N Christiansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  55     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-07     Completed Date:  1996-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
Institute for Nutrition Research, University of Oslo, Norway.
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MeSH Terms
Dietary Fats / administration & dosage,  metabolism,  pharmacology*
Fatty Acids, Monounsaturated / administration & dosage,  pharmacology*
Fatty Acids, Omega-3 / administration & dosage,  pharmacology*
Lipid Metabolism
Lipids / blood*
Liver / chemistry*,  drug effects*
Microbodies / drug effects,  metabolism
Rats, Wistar
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Omega-3; 0/Lipids

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