Document Detail

Effect of local ischaemia on the myocardial oxygen balance and its response to heart rate elevation.
MedLine Citation:
PMID:  7079459     Owner:  NLM     Status:  MEDLINE    
The capacity of ischaemic myocardium to respond to the inotropic stimulus of tachycardia was investigated in open-chest anaesthetized dogs following ligation of a branch of the anterior descending coronary artery. In two areas of the left ventricular surface (ischaemic and non-ischaemic), local coronary blood flow was measured by thermistors and isometric contractile force was recorded with strain gauge arches. NADH redox state was measured simultaneously in both regions using a two-channel surface fluorometer. It was found that ligation was followed by an immediate fall in local coronary blood flow to the ischaemic region, accompanied by a sharp elevation in NADH redox level. Local contractile force in the ischaemic region was also reduced. The non-ischaemic region showed little or no change following occlusion. Response to heart rate elevation before ligation was increased work, elevation of NADH redox levels, and increased coronary flow. Following ligation, this response was attenuated in the ischaemic region, but not abolished. It is concluded that ischaemic myocardium retains the capacity for inotropic response even when intracellular O2 levels are low.
J Sonn; A Mayevsky; B Acad; E Guggenheimer; J Kedem
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Quarterly journal of experimental physiology (Cambridge, England)     Volume:  67     ISSN:  0144-8757     ISO Abbreviation:  Q J Exp Physiol     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206873     Medline TA:  Q J Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-48     Citation Subset:  IM    
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MeSH Terms
Arteries / surgery
Coronary Circulation
Coronary Disease / physiopathology*
Heart / physiopathology
Heart Rate*
Myocardium / analysis
NAD / metabolism
Oxygen / physiology*
Reg. No./Substance:
53-84-9/NAD; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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