Document Detail


Effect of loading on the organization of the collagen fibril network in juvenile equine articular cartilage.
MedLine Citation:
PMID:  19242977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of exercise-induced loading on the collagen network of equine articular cartilage. Collagen fibril architecture at a site (1) subjected to intermittent high-intensity loading was compared with that of an adjacent site (2) sustaining continuous low-level load. From horses exposed to forced exercise (CONDEX group) or not (PASTEX group), the spatial parallelism of fibrils and the orientation angle between fibrils and the surface at depths 9 microm apart through cartilage from surface to tidemark were determined using polarized light microscopy, and expressed as parallelism index (PI) and orientation index (OI). PI was significantly higher in site 2 than 1 in CONDEX and PASTEX groups. PI was significantly higher in forced exercised horses at site 2 but not site 1. OI was significantly greater (more perpendicular to the surface) in the superficial and deep cartilage of site 2 than 1 in both CONDEX and PASTEX groups. Superficial zone OI was higher in exercised horses at site 1 but not at site 2. Exercise increased collagen parallelism and affected orientation. The site differences in OI indicate that Benninghoff's classic predominantly perpendicular arcades appear not to be a consistent architectural feature, but adapt to local forces sustained.
Authors:
Pieter A J Brama; Jaakko Holopainen; P René van Weeren; Elwyn C Firth; Heikki J Helminen; Mika M Hyttinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  27     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1226-34     Citation Subset:  IM    
Copyright Information:
(c) 2009 Orthopaedic Research Society.
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. pieter.brama@ucd.ie
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Cartilage, Articular / injuries*,  pathology,  physiology*
Collagen / physiology*
Extracellular Matrix / physiology
Female
Forelimb
Horse Diseases / pathology,  physiopathology*
Horses
Male
Microscopy, Polarization
Physical Conditioning, Animal / physiology
Weight-Bearing / physiology*
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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