Document Detail

Effect of liver glycogen content on glucose production in running rats.
MedLine Citation:
PMID:  2917936     Owner:  NLM     Status:  MEDLINE    
The influence of supranormal compared with normal hepatic glycogen levels on hepatic glucose production (Ra) during exercise was investigated in chronically catheterized rats. Supranormal hepatic glycogen levels were obtained by a 24-h fast-24-h refeeding regimen. During treadmill running for 35 min at a speed of 21 m/min, Ra and plasma glucose increased more (P less than 0.05) and liver glucogen breakdown was larger in fasted-refed compared with control rats, although the stimuli for Ra were higher in control rats, the plasma concentrations of insulin and glucose being lower (P less than 0.05) in control compared with fasted-refed rats. Also, plasma concentrations of glucagon and both catecholamines tended to be higher and muscle glycogenolysis lower in control compared with fasted-refed rats. Lipid metabolism was similar in the two groups. The results indicate that hepatic glycogenolysis during exercise is directly related to hepatic glycogen content. The smaller endocrine glycogenolytic signal in face of higher plasma glucose concentrations in fasted-refed compared with control rats is indicative of metabolic feedback control of glucose mobilization during exercise. However, the higher exercise-induced increase in Ra, plasma glucose, and liver glycogen breakdown in fasted-refed compared with control rats indicates that metabolic feedback mechanisms are not able to accurately match Ra to the metabolic needs of working muscles.
J Vissing; J L Wallace; H Galbo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  66     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-04-06     Completed Date:  1989-04-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  318-22     Citation Subset:  IM    
Department of Medical Physiology B, Panum Institute, University of Copenhagen, Denmark.
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MeSH Terms
Catecholamines / blood
Fatty Acids, Nonesterified / blood
Glucose / metabolism*
Glycogen / metabolism*
Lactates / blood
Lactic Acid
Liver / metabolism*
Pancreatic Hormones / blood
Rats, Inbred Strains
Reg. No./Substance:
0/Catecholamines; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Pancreatic Hormones; 50-21-5/Lactic Acid; 50-99-7/Glucose; 9005-79-2/Glycogen

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