Document Detail


Effect of lithium on hepatic lipid peroxidation and antioxidative enzymes under different dietary protein regimens.
MedLine Citation:
PMID:  9685047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lithium in the form of lithium carbonate was administered at a dose level of 1.1 g kg(-1) food to rats fed normal (18% protein), low-protein (LP; 8%) and high-protein (HP; 30%) diets for a period of 1 month. A highly significant (53%) increase in the level of lipid peroxidation (LPO) was observed in protein-deficient rats but this increase was marginal in rats fed an HP diet (18%). Lithium treatment of rats fed a normal diet caused a marked decrease (22%) in LPO. Lithium administration to rats fed an LP diet also reduced the raised levels of LPO to the extent of 16%. Furthermore, lithium treatment normalized the HP-induced increase in the levels of LPO. The activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) were reduced significantly in protein-deficient rats. On the other hand, an HP diet caused a decrease in SOD activity only. The activities of GPx and catalase were appreciably enhanced in lithium-treated rats. Lithium treatment to LP-fed rat markedly increased GPx activity and brought the decreased levels of SOD and catalase to within normal limits. Lithium administration to HP-fed rats did not cause any significant alteration in the activities of these antioxidative enzymes.
Authors:
A Tandon; D K Dhawan; J P Nagpaul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  18     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-09-29     Completed Date:  1998-09-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Panjab University, Chandigarh, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimanic Agents / adverse effects,  pharmacology*
Antioxidants / metabolism
Catalase / drug effects,  metabolism
Dietary Proteins*
Female
Glutathione Peroxidase / drug effects,  metabolism
Lipid Peroxidation / drug effects*
Lithium Carbonate / adverse effects,  pharmacology*
Liver / drug effects,  enzymology
Protein Deficiency
Rats
Rats, Sprague-Dawley
Superoxide Dismutase / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Antimanic Agents; 0/Antioxidants; 0/Dietary Proteins; 554-13-2/Lithium Carbonate; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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