Document Detail


Effect of lipoteichoic acid on thermotropic membrane properties.
MedLine Citation:
PMID:  9139903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoteichoic acid, diglucosyldiacylglycerol, and phosphatidylglycerol isolated from Staphylococcus aureus were embedded in dipalmitoylglycerophosphoglycerol vesicles, and their thermotropic influence on this matrix was studied by differential scanning calorimetry. The natural fatty acids of phosphatidylglycerol effected peak broadening and a decrease in molar heat capacity. These effects were more pronounced with the glycolipid, which also increased the main transition temperature. With the lipoteichoic acid mixtures, two broad main transition peaks were observed, possibly due to different levels of lipoteichoic acid in vesicles. Both peaks showed a further upshift in transition temperatures and a pronounced decrease in molar heat capacity. Since the diacylglycerol moieties of all three amphiphiles were practically identical, the differences in the thermotropic effects have to be ascribed to the different structures of the head groups. Diglucosyldiacylglycerol is proposed to exert an additional effect by hydrogen bonding the hydroxyls of the sugar rings to their phospholipid neighbors. The stronger effect of lipoteichoic acid points to dynamic interactions of the long hydrophilic chain with the vesicle surface, which stabilize the membrane structure.
Authors:
T Gutberlet; J Frank; H Bradaczek; W Fischer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bacteriology     Volume:  179     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-05-29     Completed Date:  1997-05-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2879-83     Citation Subset:  IM    
Affiliation:
Institut für Kristallographie, Berlin, Federal Republic of Germany. gutber@rz.uni-leipzig.de
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MeSH Terms
Descriptor/Qualifier:
Calorimetry, Differential Scanning
Fatty Acids / analysis
Lipopolysaccharides / chemistry*,  metabolism
Liposomes*
Models, Molecular
Phosphatidylglycerols*
Staphylococcus aureus / physiology
Teichoic Acids / chemistry*,  metabolism
Thermodynamics
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipopolysaccharides; 0/Liposomes; 0/Phosphatidylglycerols; 0/Teichoic Acids; 4537-77-3/1,2-dipalmitoylphosphatidylglycerol; 56411-57-5/lipoteichoic acid
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