| Effect of liposomal interleukin-2 on ascites-forming rat hepatoma. | |
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MedLine Citation:
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PMID: 1518292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-2 was entrapped in liposomes (Lip-IL-2) and injected into rats. The intraperitoneal injection of Lip-IL-2 into rats bearing an ascites-forming rat hepatoma (AH-66) significantly increased the survival time when compared with rats administered free IL-2 or saline-containing liposomes. The number of peritoneal exudate cells (PEC) increased markedly after intraperitoneal injection of Lip-IL-2 and consisted mainly of macrophages. The level of tumor necrosis factor alpha (TNF-alpha) and the intensity of free radicals increased in the ascites at 48 hrs after Lip-IL-2 administration, whereas TNF-alpha was not detected and the intensity of free radicals did not increase after free IL-2 administration. Our findings suggested that entrapment of IL-2 into liposomes enhanced its potential for cancer therapy, presumably by activating macrophages to produce TNF-alpha and free radicals. |
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Authors:
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H Konno; Y Maruo; A F Matin; T Tanaka; S Nakamura; S Baba; A Yamashita; T Tadakuma |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of surgical oncology Volume: 51 ISSN: 0022-4790 ISO Abbreviation: J Surg Oncol Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-10-06 Completed Date: 1992-10-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0222643 Medline TA: J Surg Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 33-7 Citation Subset: IM |
Affiliation:
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Second Department of Surgery, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / pathology* Cell Count Drug Carriers Exudates and Transudates / cytology, metabolism Free Radicals Injections, Intraperitoneal Interleukin-2 / administration & dosage*, therapeutic use Liposomes Liver Neoplasms, Experimental / drug therapy*, mortality, pathology Male Mice Mice, Inbred BALB C Rats Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Free Radicals; 0/Interleukin-2; 0/Liposomes; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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