Document Detail

Effect of lipid-lowering therapy on the progression of coronary atherosclerosis assessed by scheduled repetitive coronary arteriography.
MedLine Citation:
PMID:  7129689     Owner:  NLM     Status:  MEDLINE    
We studied 42 subjects, each of whom demonstrated significant (greater than or equal to 50%) narrowing of a non-grafted coronary artery and a baseline cholesterol level greater than 250 mg%. All patients underwent repeat scheduled coronary arteriography after 2 years on the study. Twenty-five colestipol responders (cholesterol levels reduced at least 15% within 1 month of therapy) were compared to 17 non-responders who were given 23 months of placebo after a 1 month exposure to colestipol. Baseline risk factors and demographic characteristics were similar for the two groups. In comparison to baseline arteriography, only 3 of the 25 drug-treated patients showed progression, while 8 of 17 placebo treated patients demonstrated progression (P = 0.011). Drug-treated patients demonstrated a 20% decrease in cholesterol levels, while placebo patients did not experience a significant reduction in cholesterol levels. Our study suggests that significant reduction in serum cholesterol levels is associated with a reduced likelihood of progression of coronary atherosclerotic lesions assessed by scheduled repetitive coronary arteriography in hyperlipidemic subjects demonstrating significant coronary artery narrowing on their initial arteriograms.
D T Nash; G Gensini; P Esente
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  2     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-55     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood
Colestipol / therapeutic use*
Coronary Angiography*
Coronary Disease / prevention & control*,  radiography
Hypercholesterolemia / drug therapy*,  radiography
Lipids / blood*
Middle Aged
Polyamines / therapeutic use*
Triglycerides / blood
Reg. No./Substance:
0/Lipids; 0/Polyamines; 0/Triglycerides; 50925-79-6/Colestipol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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