Document Detail

Effect of lipid admixtures on the L-dipalmitoylphosphatidylcholine subtransition.
MedLine Citation:
PMID:  3753903     Owner:  NLM     Status:  MEDLINE    
The effect of lipid admixtures on the properties of the L-dipalmitoylphosphatidylcholine (L-DPPC) subtransition is investigated by using high-sensitivity differential scanning calorimetry. The four admixtures used are D-DPPC, L-dipalmitoylphosphatidylethanolamine (L-DPPE), cholesterol, and palmitic acid. In all cases the subtransition decreases in enthalpy until disappearance with increase of the admixture concentrations. About 5-7 mol% of D-DPPC or palmitic acid are sufficient for abolishment (without position shifts) of the subtransition, while, on addition of L-DPPE or cholesterol, it persists up to about 20 mol% of the admixture and its disappearance is accompanied by a slight shift to higher temperatures. These data are tentatively interpreted in terms of lateral mixing of L-DPPC and admixture as indicating compound formation with D-DPPC and palmitic acid, and clustering of L-DPPE and cholesterol.
A I Boyanov; R D Koynova; B G Tenchov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  39     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-04     Completed Date:  1986-04-04     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
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MeSH Terms
Calorimetry, Differential Scanning
Models, Biological
Palmitic Acid
Palmitic Acids
Pulmonary Surfactants*
Reg. No./Substance:
0/Liposomes; 0/Palmitic Acids; 0/Phosphatidylethanolamines; 0/Pulmonary Surfactants; 3026-45-7/1,2-dipalmitoyl-3-phosphatidylethanolamine; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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