Document Detail


Effect of lintitript, a new CCK-A receptor antagonist, on gastric emptying of a solid-liquid meal in humans.
MedLine Citation:
PMID:  9712175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of cholecystokinin (CCK) in the regulation of gastric emptying of physiological meals containing solids and liquids in humans remains controversial. We studied the role of endogenous CCK in the emptying of a solid/liquid meal administering the new, highly specific and potent CCK-A receptor antagonist lintitript. Gastric emptying was assessed in nine healthy male volunteers using a randomized, double blind, two-period crossover design with oral lintitript (15 mg 1 h prior to meal intake) or placebo on two different days. After ingestion of a pancake (570 kcal) labelled with 500 microCi of 99mTc-sulfur colloid and 500 ml 10% dextrose containing 80 microCi. 111In-DTPA, subjects were studied in a sitting position, using a dual-headed gamma camera. Plasma CCK and pancreatic polypeptide (PP) were measured by a specific RIA. Lintitript distinctly accelerated gastric emptying of solids, while gastric emptying of liquids was not significantly altered. The lag period was shortened by 20% (P<0.05), AUC and half emptying time of solid emptying were lowered by 12% and 13%, respectively (P<0.03). Lintitript markedly increased postprandial plasma CCK release (P<0.001) while distinctly reducing postprandial PP levels (P<0.01) as compared to placebo. These data provide further evidence for a significant role of CCK in the regulation of gastric emptying of solids. The study demonstrates for the first time the marked gastrokinetic properties of the new CCK-A receptor antagonist lintitript in humans.
Authors:
C Kreiss; W Schwizer; J Borovicka; J B Jansen; C Bouloux; R Pignol; A Bischof Delaloye; M Fried
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  74     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, University Hospital, Lausanne, Switzerland. ramanikreiss@pol.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Cholecystokinin / blood
Cross-Over Studies
Double-Blind Method
Gastric Emptying*
Humans
Indoleacetic Acids / pharmacology*
Male
Pancreatic Polypeptide / blood
Receptor, Cholecystokinin A
Receptors, Cholecystokinin / antagonists & inhibitors*
Thiazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Indoleacetic Acids; 0/Receptor, Cholecystokinin A; 0/Receptors, Cholecystokinin; 0/Thiazoles; 136381-85-6/SR 27897; 59763-91-6/Pancreatic Polypeptide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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