Document Detail

Effect of linseed addition on the expression of some lipid metabolism genes in the adipose tissue of young Italian Simmental and Holstein bulls.
MedLine Citation:
PMID:  23048135     Owner:  NLM     Status:  Publisher    
The objective of this trial was to determine the effect of breed and long-term dietary linseed addition on composition of fatty acids and expression of some genes involved in the lipid metabolism within s.c. adipose tissue of young bulls. Italian Simmental and Holstein bulls (n = 16/breed) were fed a corn silage-grass hay diet with, or without, 8% (DM basis) whole, ground linseed. Inclusion of linseed - rich in α-linoleic acid (C18:3n-3) - increased (P < 0.05) the proportions of linolelaidic (C18:2n-6trans), γ-linolenic (C18:3n-6), C18:3n-3, and rumenic (cis9,trans11 CLA) acids, as well as total n-3 fatty acid, total PUFA, and PUFA:SFA, but decreased (P < 0.05) weight percentages of myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), palmitelaidic (C16:1n-9trans), margaric (C17:0) acids, along with n-6:n-3, in the s.c. fat of young bulls. Even though PUFA were similar (P ≥ 0.23) between bull breeds, s.c. fat from Holstein bulls had greater (P < 0.05) proportions of tridecylic acid (C13:0), myristoleic (C14:1) and palmitoleic (C16:1n-9cis) acids, and a lower (P < 0.05) proportion of margaric (C17:0) acid than s.c. fat from Simmental bulls. Feeding linseed decreased (P < 0.05) the expression of stearoyl CoA desaturase (SCD) and lipoprotein lipase (LPL) gene without affecting (P ≥ 0.19) fatty acid synthase (FASN), leptin (LEP), and peroxisome proliferators-activated receptor gamma 2 (PPARγ2) mRNA in the s.c. fat of bulls; however, there was no (P ≥ 0.11) effect of bull breed, nor an interactive effect of breed and linseed (P ≥ 0.23), on gene expression. Expression of PPARγ2 was positively correlated with SCD (r = 0.454; P = 0.01), LEP (r = 0.500; P < 0.01), and LPL (r = 0.531; P < 0.01) mRNA, indicating that PPARγ2 increases the expression of genes involved in lipogenesis.
M Corazzin; S Bovolenta; E Saccà; G Bianchi; E Piasentier
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Agricultural and Environmental Science, University of Udine, Udine 33100, Italy.
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