Document Detail

Effect of linoleic acid intake on growth of infants with cystic fibrosis.
MedLine Citation:
PMID:  8615359     Owner:  NLM     Status:  MEDLINE    
Essential fatty acid deficiency as a result of inadequate linoleic acid impairs growth in healthy infants and is common in infants with malabsorption due to cystic fibrosis (CF). We investigated the effect of dietary linoleic acid intake on the growth of infants with CF. In this study, predigested formula preparations A and B, with linoleic acid contents of 12% and 7% of energy, respectively, were fed before and after 1989 to infants enrolled in the evaluation and treatment protocol of the Wisconsin CF Neonatal Screening Project. Outcome was assessed from height-for-age (HAZ) and weight-for-age (WAZ) Z scores on follow-up exams during the first year. Baseline characteristics did not differ significantly between groups A (n = 43) and B (n = 33). At diagnosis, 53% of the enrolled infants (n = 76) showed low plasma linoleic acid concentrations and 22% had a high ratio of triene to tetraene. After correcting for the effect of potentially confounding variables, we found that HAZ (by .27, P < 0.05) and WAZ (by 0.26, P = 0.081) were higher in group A than in group B. This occurred despite a significantly higher energy intake in group B. This difference was most pronounced between 6 and 9 mo of age. Our results suggest that a high linoleic acid content in formula benefits infants with CF because it optimizes nutrition, growth, and feeding efficiency.
A W van Egmond; M R Kosorok; R Koscik; A Laxova; P M Farrell
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  63     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-06-06     Completed Date:  1996-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  746-52     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Wisconsin Clinical Science Center, Madison, USA.
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MeSH Terms
Age Factors
Body Height / drug effects,  physiology
Body Weight / drug effects,  physiology
Cystic Fibrosis / complications,  diet therapy*,  physiopathology
Deficiency Diseases / epidemiology
Energy Intake
Fatty Acids, Essential / blood,  deficiency
Growth / drug effects*
Growth Disorders / drug therapy,  etiology,  physiopathology
Infant Food* / analysis
Infant, Newborn
Linoleic Acid
Linoleic Acids / administration & dosage,  pharmacology*,  therapeutic use
Longitudinal Studies
Wisconsin / epidemiology
Grant Support
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Linoleic Acids; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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