| Effect of linoleic acid intake on growth of infants with cystic fibrosis. | |
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MedLine Citation:
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PMID: 8615359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Essential fatty acid deficiency as a result of inadequate linoleic acid impairs growth in healthy infants and is common in infants with malabsorption due to cystic fibrosis (CF). We investigated the effect of dietary linoleic acid intake on the growth of infants with CF. In this study, predigested formula preparations A and B, with linoleic acid contents of 12% and 7% of energy, respectively, were fed before and after 1989 to infants enrolled in the evaluation and treatment protocol of the Wisconsin CF Neonatal Screening Project. Outcome was assessed from height-for-age (HAZ) and weight-for-age (WAZ) Z scores on follow-up exams during the first year. Baseline characteristics did not differ significantly between groups A (n = 43) and B (n = 33). At diagnosis, 53% of the enrolled infants (n = 76) showed low plasma linoleic acid concentrations and 22% had a high ratio of triene to tetraene. After correcting for the effect of potentially confounding variables, we found that HAZ (by .27, P < 0.05) and WAZ (by 0.26, P = 0.081) were higher in group A than in group B. This occurred despite a significantly higher energy intake in group B. This difference was most pronounced between 6 and 9 mo of age. Our results suggest that a high linoleic acid content in formula benefits infants with CF because it optimizes nutrition, growth, and feeding efficiency. |
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Authors:
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A W van Egmond; M R Kosorok; R Koscik; A Laxova; P M Farrell |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 63 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-06-06 Completed Date: 1996-06-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 746-52 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Wisconsin Clinical Science Center, Madison, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Body Height / drug effects, physiology Body Weight / drug effects, physiology Cystic Fibrosis / complications, diet therapy*, physiopathology Deficiency Diseases / epidemiology Energy Intake Fatty Acids, Essential / blood, deficiency Female Growth / drug effects* Growth Disorders / drug therapy, etiology, physiopathology Humans Infant Infant Food* / analysis Infant, Newborn Linoleic Acid Linoleic Acids / administration & dosage, pharmacology*, therapeutic use Longitudinal Studies Male Prevalence Wisconsin / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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DK34108/DK/NIDDK NIH HHS; RR03186/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 0/Linoleic Acids; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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