| Effect of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of adhesion molecules on human neutrophils. | |
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MedLine Citation:
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PMID: 9332699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of CD11b/ CD18, CD11c/CD18 integrins and L-selectin on human neutrophils were studied by flow cytometry in a whole blood assay. None of these compounds had any effect on the basal expression of CD11b, CD11c, or L-selectin in the concentration range of 20-100 microM. However, linoleic acid at a concentration of 1000 microM slightly up-regulated CD11b and CD11c by a factor of 2.1 and 1.7, respectively. Linoleic acid, linoleic acid anilide, and arachidonic acid did not affect the formyl-methionyl-leucyl-phenylalanine induced up-regulation of CD11b or CD11c. However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively. Likewise, arachidonic acid at 40 microM inhibited the PMA-induced expression of CD11b by 19%. Our results suggest that linoleic acid, linoleic acid anilide, and arachidonic acid do not dramatically affect the expression of leukocyte adhesion molecules in a whole blood assay. |
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Authors:
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K M Heiskanen; S Münzing; F Krombach; K M Savolainen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of toxicology Volume: 71 ISSN: 0340-5761 ISO Abbreviation: Arch. Toxicol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-11-18 Completed Date: 1997-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 627-32 Citation Subset: IM |
Affiliation:
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University of Kuopio, Department of Pharmacology and Toxicology, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anilides
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toxicity* Antigens, CD18 / biosynthesis, genetics Arachidonic Acid / toxicity* Cell Adhesion Molecules / biosynthesis*, genetics Flow Cytometry Humans Integrin alphaXbeta2 / biosynthesis, genetics L-Selectin / biosynthesis, genetics Linoleic Acid / toxicity* Linoleic Acids / toxicity* Macrophage-1 Antigen / biosynthesis, genetics N-Formylmethionine Leucyl-Phenylalanine Neutrophils / drug effects*, metabolism Receptors, Leukocyte-Adhesion / biosynthesis*, genetics Tetradecanoylphorbol Acetate |
| Chemical | |
Reg. No./Substance:
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0/Anilides; 0/Antigens, CD18; 0/Cell Adhesion Molecules; 0/Integrin alphaXbeta2; 0/Linoleic Acids; 0/Macrophage-1 Antigen; 0/Receptors, Leukocyte-Adhesion; 126880-86-2/L-Selectin; 16561-29-8/Tetradecanoylphorbol Acetate; 19878-10-5/linoleylanilide; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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