Document Detail

Effect of limb ischaemia on blood pressure and the blood pressure-heart rate reflex in the rat.
MedLine Citation:
PMID:  6514997     Owner:  NLM     Status:  MEDLINE    
The effects of bilateral hind-limb ischaemia on blood pressure and on the blood pressure-heart rate reflex have been studied in the rat. Limb ischaemia increased blood pressure and decreased the elevation and slope of the regression line describing the relationship between heart period (H.P.) and mean arterial pressure (M.A.P.). Nociceptive afferents from muscle receptors using long fibre tracts in the anterolateral part of the spinal cord seem to be responsible for the changes seen. The changes in the blood pressure-heart rate reflex were mediated by a combination of vagal inhibition and sympathetic activation. The efferent pathway for the pressor effect was in the sympathetic outflow. Central catecholaminergic neurones were involved in the pressor effect of limb ischaemia but not in the changes in the blood pressure-heart rate reflex. Electrolytic lesions in the posterior hypothalamus attenuated the inhibition of the reflex and it is suggested that neurones in the defence area may be activated by limb ischaemia. The interaction between limb ischaemia and the H.P.-M.A.P. relationship was not affected by opioid antagonists. After the period of ischaemia there was an increase in the elevation of the regression line describing the relationship between H.P. and M.A.P. which was secondary to the fall in body temperature characteristic of this phase of the response to injury.
W S Redfern; R A Little; H B Stoner; H W Marshall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Quarterly journal of experimental physiology (Cambridge, England)     Volume:  69     ISSN:  0144-8757     ISO Abbreviation:  Q J Exp Physiol     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-02-04     Completed Date:  1985-02-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8206873     Medline TA:  Q J Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  763-79     Citation Subset:  IM    
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MeSH Terms
Afferent Pathways / physiopathology
Autonomic Agents / pharmacology
Blood Pressure* / drug effects
Extremities / blood supply
Heart Rate* / drug effects
Ischemia / physiopathology*
Muscles / blood supply
Phenylephrine / pharmacology
Pressoreceptors / drug effects,  physiopathology
Rats, Inbred Strains
Reflex* / drug effects
Spinal Cord / physiopathology
Reg. No./Substance:
0/Autonomic Agents; 59-42-7/Phenylephrine

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