Document Detail

Effect of lifetime intake of organically bound tritium and tritiated water on the oocytes of rats.
MedLine Citation:
PMID:  6709828     Owner:  NLM     Status:  MEDLINE    
Rats were continuously exposed to constant activity of tritium in drinking water (HTO group) or to tritium organically bound in food (T-food group) in the period from conception of F1 generation through maturity. Female offspring were killed at the age of 21 and 71 days and the oocytes in their ovaries were counted. Mean dose rates absorbed in the ovaries were for the HTO groups 7.25 +/- 0.37 and 14.73 +/- 0.79 mGy/day and for the T-food group 4.84 +/- 0.25 mGy/day. Reduction in the oocyte number in the ovaries of females exposed to tritiated food was bigger than in the ovaries of females exposed to tritiated water. The dependence of the survival of small oocytes on the dose rate and the corresponding total accumulated dose had an exponential character. The damaging effect of tritium was for the period from conception to 21 days of age bigger than from 21 to 71 days of age. Of all stages of oocyte development, the highest sensitivity to tritium irradiation was observed in small oocytes and oocytes with one complete layer of follicle cells. As a result, relative number of growing and large oocytes increased.
Z Pietrzak-Flis; M Wasilewska-Gomułka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  23     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  1984  
Date Detail:
Created Date:  1984-05-23     Completed Date:  1984-05-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
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MeSH Terms
Animal Feed
Cell Count
Oocytes / radiation effects*
Ovary / analysis
Rats, Inbred Strains
Tritium / pharmacology*,  urine
Reg. No./Substance:
10028-17-8/Tritium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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