| Effect of lifestyle and/or statin treatment on soluble markers of atherosclerosis in hypertensives. | |
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MedLine Citation:
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PMID: 17852781 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the independent and combined effects of lifestyle changes and statin treatment on soluble markers of atherosclerotic activity. DESIGN: The study was a randomised, 2 x 2 factorial 1 year intervention trial. Participants (n=177) were sedentary, drug-treated, hypertensive men (aged 40-74 years). They were randomised to placebo, lifestyle intervention (diet and physical activity), fluvastatin 40 mg, or the combination of lifestyle and fluvastatin. RESULTS: Lifestyle intervention significantly reduced intercellular adhesion molecule-1 (sICAM-1) compared to usual care (p=0.003). Thrombomodulin level remained higher among individuals receiving lifestyle intervention (p=0.025). sICAM-1 was less reduced among fluvastatin treated participants compared to the placebo treated (p=0.029). Changes of blood pressure, weight or waist circumference were not significantly different between treatment groups. Individuals who achieved improvement of classical risk factors also had a significant reduction of endothelial markers (E-selectin, von Willebrands factor, tissue plasminogen activator antigen). CONCLUSIONS: One year of lifestyle intervention reduced the level of sICAM-1 in sedentary, drug-treated hypertensives, in spite of no impact on traditional risk factors. Low dose fluvastatin had no beneficial effect on the measured markers. |
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Authors:
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Anne Hjelstuen; Sigmund A Anderssen; Ingar Holme; Ingebjørg Seljeflot; Tor Ole Klemsdal |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 41 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-11-09 Completed Date: 2008-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: England |
Other Details:
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Languages: eng Pagination: 313-20 Citation Subset: IM |
Affiliation:
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Research Forum, Ullevål University Hospital, Oslo, Norway. anne@hjelstuen.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteriosclerosis / diagnosis, drug therapy* Biological Markers Disintegrins / pharmacology*, therapeutic use Endothelins / drug effects Female Hemostasis / drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*, therapeutic use Hypertension / diagnosis, drug therapy* Inflammation Intercellular Adhesion Molecule-1 Life Style* Male Middle Aged Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Disintegrins; 0/Endothelins; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/flavostatin; 126547-89-5/Intercellular Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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